Results 21 to 30 of about 328,126 (218)

Association Between Dynamic Trends of Functional Disability and Poverty Among People Aged 45 and Over

Frontiers in Public Health, 2022
BackgroundThe disability problem has become prominent with the acceleration of the global aging process. Individual disability is associated with economic conditions and contributes to family poverty.
Hui Liao, Chaoyang Yan, Ying Ma, Jing Wang, Jing Wang, Jing Wang   +5 more
doaj   +1 more source

Functional disability among middle-aged adults in India: Prevalence and correlates of a national study

Asian Journal of Social Health and Behavior, 2021
Introduction: There is a lack of research in investigating functional disability (FD) among middle-aged populations. The aim of the study was to estimate the prevalence and correlates of FD among middle-aged persons in India.
Karl Peltzer
doaj   +1 more source

Is psychological distress associated with carpal tunnel syndrome symptoms and nerve conduction study findings? A case–control study from Syria

Brain and Behavior, 2022
Background Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the median nerve at the wrist which causes severe symptoms. However, psychological aspects can affect patients' perception of this pain and can cause similar pain in some ...
Aya Alsharif, Aya Al Habbal, Yaman Daaboul, Lama Al Hawat, Osama Al Habbal, Ameer Kakaje   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Health related quality of life among people with mental illness: The role of socio-clinical characteristics and level of functional disability

Frontiers in Public Health, 2023
BackgroundPeople with mental illness (PWMI) have declining health related quality of life (HRQoL), which is frequently equivalent to or greater than that of medical disorders.
Semira Defar, Yacob Abraham, Yared Reta, Bedilu Deribe, Meskerem Jisso, Tomas Yeheyis, Kurabachew Mengistu Kebede, Bereket Beyene, Mohammed Ayalew   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The effect of internet use on depressive symptoms in middle-aged and older adults with functional disability: the mediating role of social isolation

Frontiers in Public Health, 2023
ObjectiveThe popularization of the internet provides the possibility to improve the depressive symptoms (DS) and social isolation of middle-aged and older adults with functional disability.
Man Wu, Chaoyang Li, Xueyang Zhao, Ting Hu, Lijuan Zeng, Yiqing Yu, Fen Yang, Yangyang Han   +7 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Depression in patients with chronic low back pain

Egyptian Rheumatology and Rehabilitation, 2019
Background Low back pain is a common health issue affecting at least 80% of individuals during their lifetime. It is usually recurrent and develops into chronic low back pain (CLBP).
N Nassar, N Assaf, D Farrag, D Ibrahim, A Al-Sheekh   +4 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source