Results 101 to 110 of about 1,772,774 (288)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily. [PDF]

, 2017
Insight regarding how diverse enzymatic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and evolutionary biology, and for the exploitation of enzymes for biotechnology.
Akiva, Eyal, Babbitt, Patricia C, Copp, Janine N, Tokuriki, Nobuhiko   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Relationships between functional alpha and beta diversities of flea parasites and their small mammalian hosts

Parasitology
We studied the relationships between functional alpha and beta diversities of fleas and their small mammalian hosts in 4 biogeographic realms (the Afrotropics, the Nearctic, the Neotropics and the Palearctic), considering 3 components of alpha diversity (
Boris R. Krasnov, Irina S. Khokhlova, M. Fernanda López Berrizbeitia, Sonja Matthee, Juliana P. Sanchez, Georgy I. Shenbrot, Luther van der Mescht   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

MICROBIAL CHARACTERIZATION OF ABANDONED MINING AREA OF SIDI KAMBER NORTH-EAST OF ALGERI [PDF]

, 2018
The ecological importance of soil bacteria is not limited to their number or biomass, although these parameters contribute greatly. Indeed, their main asset lies in their great genetic and functional diversity.
Bouchaala, Laid, Bouyahmed, Hani, Charchar, Nabil, Gherib, Abd El-fatteh, Lehout, Amel   +4 more
core  

Complex dynamics in coevolution models with ratio-dependent functional response

, 2009
We explore the complex dynamical behavior of two simple predator-prey models of biological coevolution that on the ecological level account for interspecific and intraspecific competition, as well as adaptive foraging behavior.
Bascompte, Caldarelli, Chowdhury, Chowdhury, Christensen, Crosby, di Collobiano, Drossel, Drossel, Eigen, Eigen, Filotas, Gavrilets, Gavrilets, Gavrilets, Getz, Hall, Kauffman, Kauffman, Krebs, Krebs, Kuang, Martinez, Murray, Namba, Newman, Newman, Nunes Amaral, Per Arne Rikvold, Procaccia, Qin, Quince, Quince, Resit, Rikvold, Rikvold, Rikvold, Rikvold, Rossberg, Rossberg, Sevim, Skalski, Solé, Thompson, Thompson, Verhulst, Yoshida, Yoshida, Zia   +48 more
core   +1 more source

Discourse ethics and functional diversity [PDF]

, 2018
En este artículo hacemos un breve recorrido por algunas de las ideas fundamentales de la ética del diálogo (K.O. Apel, J. Habermas y A. Cortina) considerando que constituye un enfoque adecuado para afrontar las obligaciones de justicia con la totalidad
Aparicio Payá, Manuel
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A reappraisal of the vegetation from the dinosaur-bearing Bahariya Formation (lower Cenomanian; Cretaceous), Egypt

Swiss Journal of Palaeontology
The Bahariya Formation of the northern Western Desert, Egypt, is well-known for its plentiful and diverse vertebrate fossil assemblages, especially dinosaurs, and also eminent for its rich fossil macroflora.
Clément Coiffard, Haytham El Atfy, Mona H. Darwish, Ahmed Mohamed   +3 more
doaj   +1 more source