Results 111 to 120 of about 1,214,259 (255)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Environmental determinants and spatial mismatch of mammal diversity measures in Colombia [PDF]
Animal Biodiversity and Conservation, 2016 Including complementary diversity measures into ecological and conservation studies should improve our ability to link species assemblages to ecosystems.
González–Maya, J. F. +4 more
doaj
The Rhetorical Discourse Revealing The Indonesians Characters [PDF]
, 2017 Indonesia comprises of many tribes and language spreading all over its islands from Sabang to Merauki. The tribes and their languages are unique symbolizing that they are heterogeneous society who live in a place named Indonesia.
Muqit, Abd
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Evolutionary dynamics from a variational principle
, 2009 We demonstrate with a thought experiment that fitness-based population dynamical approaches to evolution are not able to make quantitative, falsifiable predictions about the long-term behavior of evolutionary systems. A key characteristic of evolutionary
Hanel, Rudolf +2 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Enterprise performance and the functional diversity of social capital [PDF]
Entrepreneurial networks are multifunctional; they can be used to access information about technologies and markets or to reduce uncertainties. A network’s function affects its structure and both the magnitude and nature of the impact that it has on ...
Abigail Barr
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A glass half full or half empty?: A comparison of diversity statements among Russell group UK vs US Research universities [PDF]
, 2010 The term diversity is ubiquitous in university mission statements, strategic plans, recruitment brochures, and university websites. This paper argues aims to compare university diversity statements from US Research Tier 1 universities with those from the
Morrish, L, O'Mara, K
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