Results 91 to 100 of about 1,105,937 (292)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A numerical technique based on Lucas polynomials together with standard and Chebyshev-Lobatto collocation points for solving functional integro-differential equations involving variable delays

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
In this paper, a new numerical matrix-collocation technique is consideredto solve functional integro-differential equations involving variable delaysunder the initial conditions.
Sevin Gümgüm, Nurcan Baykuş Savaşaneril, Ömür Kıvanç Kürkçü, Mehmet Sezer   +3 more
doaj   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Properties of a Composite Material with Mixed Imperfect Contact Conditions

Mathematical Modelling and Analysis, 2016
We present an analytical solution of a mixed boundary value problem for an unbounded 2D doubly periodic domain which is a model of a composite material with mixed imperfect interface conditions.
Luıs Filipe Pinheiro de Castro, Ekaterina Pesetskaya   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Generalization of sum representation functional equations-I

International Journal of Mathematics and Mathematical Sciences, 1979
This paper contains the solution of a functional equation which is a generalization of a functional equation arising in a characterization of directed divergence and inaccuracy.
Pl. Kannappan, V. Sathyabhama
doaj   +1 more source

Functional representation of the Ablowitz-Ladik hierarchy. II

, 2002
In this paper I continue studies of the functional representation of the Ablowitz-Ladik hierarchy (ALH). Using formal series solutions of the zero-curvature condition I rederive the functional equations for the tau-functions of the ALH and obtain some ...
Ablowitz M J, Ablowitz M J, Ablowitz M J, Bogdanov L V, Jimbo M, Miller P D, Miwa T, Newell A C, Suris Yu B, Vekslerchik V E, Vekslerchik V E, Vekslerchik V E, Vekslerchik V E, Vekslerchik V E, Zakharov V E   +14 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Existence of positive solutions of linear delay difference equations with continuous time

Electronic Journal of Qualitative Theory of Differential Equations, 2015
Consider the delay difference equation with continuous time of the form \[x(t)-x(t-1)+\sum_{i=1}^mP_i(t)x(t-k_i(t))=0,\qquad t\ge t_0,\] where $P_i\colon[t_0,\infty)\mapsto\mathbb{R}$, $k_i\colon[t_0,\infty)\mapsto \{2,3,4,\dots\}$ and $\lim_{t\to\infty}(
George Chatzarakis, István Győri, Hajnalka Péics, Ioannis Stavroulakis   +3 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source