Results 81 to 90 of about 1,105,937 (292)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Treatments of the exchange energy in density-functional theory

, 2008
Following a recent work [Gal, Phys. Rev. A 64, 062503 (2001)], a simple derivation of the density-functional correction of the Hartree-Fock equations, the Hartree-Fock-Kohn-Sham equations, is presented, completing an integrated view of quantum mechanical
Gál T., Parr R. G., Slater J. C.
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Aspects of the Functional Renormalisation Group

, 2005
We discuss structural aspects of the functional renormalisation group. Flows for a general class of correlation functions are derived, and it is shown how symmetry relations of the underlying theory are lifted to the regularised theory. A simple equation
Alexandre, Alexandre, Alexandre, Alexandre, Alkofer, Alkofer, Aoki, Aoki, Aoki, Arrizabalaga, Bagnuls, Ball, Baym, Bergerhoff, Berges, Berges, Berges, Berges, Bervillier, Blaizot, Blaizot, Blaizot, Blaizot, Blaizot, Blaizot, Bonanno, Bonini, Bonini, Bonini, Bonini, Bonini, Bonini, Bonini, Branchina, Braun, Buchbinder, Callan, Canet, Canet, Carrington, Collins, Comellas, Comellas, Cooper, Cooper, Cornwall, Delamotte, Dupuis, D’Attanasio, D’Attanasio, D’Attanasio, D’Attanasio, Ellwanger, Ellwanger, Ellwanger, Ellwanger, Ellwanger, Ellwanger, Ellwanger, Ellwanger, Falkenberg, Fischer, Fischer, Fischer, Fischer, Fischer, Fischer, Fischer, Fisher, Floreanini, Ford, Freire, Gell-Mann, Generowicz, Gies, Gies, Gies, Gies, Ginsparg, Gomis, Honerkamp, Hurd, Igarashi, Igarashi, Jacquot, Jaeckel, Jan M. Pawlowski, Kadanoff, Keller, Keller, Keller, Keller, Latorre, Lauscher, Lenz, Lerche, Liao, Liao, Liao, Liao, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Litim, Luttinger, Maas, Morris, Morris, Morris, Morris, Morris, Morris, Morris, Nandori, Nicoll, Oleszczuk, Panza, Papp, Pawlowski, Pawlowski, Pawlowski, Pawlowski, Pawlowski, Pernici, Polchinski, Polonyi, Polonyi, Polonyi, Polonyi, Reinhardt, Reinosa, Reinosa, Reuter, Reuter, Reuter, Reuter, Reuter, Roberts, Rosten, Rosten, Rosten, Salmhofer, Salmhofer, Schaefer, Schutz, Simionato, Simionato, Simionato, Stevenson, Stueckelberg, Symanzik, van Hees, van Hees, Verschelde, von Smekal, von Smekal, Warr, Wegner, Wetterich, Wetterich, Wilson, Wilson, Wilson, Zappala, Zappalà, Zinn-Justin, Zwanziger, Zwanziger, Zwanziger   +179 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

18th International Conference on Functional Equations and Inequalities, Będlewo, Poland, July 9-15, 2019

Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2019
Report from the conference.
Report of Meeting
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A Noninformative Prior on a Space of Distribution Functions

Entropy, 2017
In a given problem, the Bayesian statistical paradigm requires the specification of a prior distribution that quantifies relevant information about the unknowns of main interest external to the data.
Alexander Terenin, David Draper
doaj   +1 more source

Eigenvalues and Functional Equations [PDF]

Proceedings of the American Mathematical Society, 1957
Abstract : The purpose of this paper was to illustrate how the techniques of the theory of dynamic programming may be used to convert a number of eigenvalue problems, where one is interested only in maximum or minimum values, into problems involving recurrence relations.
openaire   +2 more sources