Results 21 to 30 of about 535,935 (302)

Modelling and in vitro testing of the HIV-1 Nef fitness landscape. [PDF]

, 2019
An effective vaccine is urgently required to curb the HIV-1 epidemic. We have previously described an approach to model the fitness landscape of several HIV-1 proteins, and have validated the results against experimental and clinical data.
Barton, John P, Chakraborty, Arup K, Mahiti, Macdonald, Mann, Jaclyn K, Murakowski, Dariusz K, Mwimanzi, Phillip, Ndung'u, Thumbi, Rajkoomar, Erasha, Toyoda, Mako, Ueno, Takamasa   +9 more
core   +2 more sources

Fitness functions for RNA structure design

Nucleic Acids Research, 2022
Abstract An RNA design algorithm takes a target RNA structure and finds a sequence that folds into that structure. This is fundamentally important for engineering therapeutics using RNA. Computational RNA design algorithms are guided by fitness functions, but not much research has been done on the merits of these functions.
Max Ward, Eliot Courtney, Elena Rivas
openaire   +2 more sources

Sex allocation and reproductive success in the andromonoecious perennial, Solanum carolinense (Solanaceae). II. paternity and functional gender [PDF]

, 2017
The work was supported by a National Science Foundation Doctoral Dissertation Improvement grant (DEB‐9411513), by the Society for Sigma Xi, and by a Hutcheson Memorial Forest grant.According to Bateman's principle, male fitness in entomophilous plant ...
Elle, E, Meagher, Thomas Robert
core   +1 more source

Circuit layout evolution: An evolvable hardware approach [PDF]

, 1999
The evolvable hardware technique is based on evolving the functionality and connectivity of a rectangular array of logic cells in addition to the layout of this may. The evolutionary process contains two main steps.
Kalganova, T, Miller, J F
core   +1 more source

A function fitting method

Journal of Applied Analysis, 2020
Abstract In this article, we describe a function fitting method that has potential applications in machine learning and also prove relevant theorems. The described function fitting method is a convex minimization problem which can be solved using a gradient descent algorithm.
openaire   +2 more sources

Gene expression drives the evolution of dominance. [PDF]

, 2018
Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits.
A Durvasula, A Platt, AF Agrawal, B Charlesworth, BM Henn, BY Kim, CD Huber, CD Huber, D Enard, D Ortega-Del Vecchyo, D Szklarczyk, DJ Balick, F Gao, F Manna, FH Shaw, H Kacser, HA Orr, I Frumkin, J Yang, JBS Haldane, JS Sanjak, KE Lohmueller, KM Teshima, LD Hurst, MA DePristo, MJ Simmons, N Phadnis, P Cingolani, P Lamesch, PY Novikova, RA Fisher, RD Hernandez, RN Gutenkunst, S Glémin, S Ossowski, S Williamson, S Wright, SH Williamson, T Bedford, T Kawakatsu, T Mukai, TI Gossmann, TT Hu, X Zheng, YB Simons   +44 more
core   +1 more source

Visual function and fitness to drive [PDF]

British Medical Bulletin, 2008
Driving is recognized to be a visually intensive task and accordingly there is a legal minimum standard of vision required for all motorists. The purpose of this paper is to review the current United Kingdom (UK) visual requirements for driving and discuss the evidence base behind these legal rules.
Aachal, Kotecha, Alexander, Spratt, Ananth, Viswanathan   +2 more
openaire   +3 more sources

Arm-crank training improves postural stability and physical functioning in older people [PDF]

, 2018
Background: Arm crank ergometry (ACE) has been shown to elicit marked improvements in lower body exercise capacity among older individuals. It is currently unknown whether ACE is effective in alleviating functional consequences of aging, such as balance ...
Duncan, M., Hill, M., Oxford, S., Price, M.   +3 more
core   +1 more source

Reference biomechanical parameters and natural asymmetry among runners across the age spectrum without a history of running-related injuries

Frontiers in Sports and Active Living
IntroductionRunning biomechanics and expected mechanical asymmetries with no history of running-related injuries, and (2) determine whether age influenced gait parameter asymmetry.MethodsThis cross-sectional study included 250 runners were used to test ...
Heather K. Vincent, Reed Popp, Orlando Cicilioni, Orlando Cicilioni, Kevin R. Vincent, Lydia Pezzullo, Matthew Martenson, Ryan M. Nixon   +7 more
doaj   +1 more source

Comparative Biomechanical Strategies of Running Gait Among Healthy and Recently Injured Pediatric and Adult Runners

Bioengineering
Biomechanical strategies of running gait were compared among healthy and recently injured pediatric and adult runners (N = 207). Spatiotemporal, kinematic, and kinetic parameters (ground reaction force [GRF], vertical average loading rate [VALR]) and leg
Cole Verble, Ryan M. Nixon, Lydia Pezzullo, Matthew Martenson, Kevin R. Vincent, Heather K. Vincent   +5 more
doaj   +1 more source