Results 71 to 80 of about 3,570,719 (299)

Fitting a Step Function to a Point Set [PDF]

Algorithmica, 2008
We consider the problem of fitting a step function to a set of points. More precisely, given an integer k and a set P of n points in the plane, our goal is to find a step function f with k steps that minimizes the maximum vertical distance between f and all the points in P.
Hervé Fournier, Antoine Vigneron
openaire   +6 more sources

Functional training reduces body fat and improves functional fitness and cholesterol levels in postmenopausal women: A randomized clinical trial

, 2017
BACKGROUND: This randomized clinical trial with concealed allocations, and blinding of the assessors and the data analyst, was aimed at determining the effects of 16 weeks of functional training on the body composition, functional fitness and lipid ...
Fortaleza, Ana C. [UNESP], Gobbo, Luis A. [UNESP], Codogno, Jamile S. [UNESP], Neves, Lucas M. [UNESP], Gobbi, Sebastião [UNESP], Diniz, Tiego A. [UNESP], Rossi, Fabrício E. [UNESP], Freitas, Ismael F. [UNESP]   +7 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effects of 8-week of fitness classes on blood pressure, body composition, and physical fitness

, 2020
BACKGROUND: Fitness activities such as indoor cycling (IC), Zumba® (ZU) and body pump (BP) are practiced by large segments of population. There are no studies showing which kind of fitness activity can produce more health benefits.
Carlos-Vivas, Jorge, Pérez-Gómez, Jorge, Chavarrias, Manuel, Barrantes-Martín, Beatriz   +3 more
core   +1 more source

Soil-transmitted helminth infections and physical fitness in school-aged Bulang children in southwest China : results from a cross-sectional survey [PDF]

, 2012
BACKGROUND: Chronic soil-transmitted helminth (STH) infections have been associated with reduced physical fitness, but available evidence is limited. The aim of this cross-sectional survey was to assess the feasibility of measuring children's physical ...
Peter Steinmann, Wang Jian, Steinmann Peter, Utzinger, Jürg, Zhou, Hui, Utzinger Jürg, Yap, Peiling, Zun-Wei Du, Fang-Wei Wu, Du Zun-Wei, Ran Chen, Xiao-Nong Zhou, Jürg Utzinger, Hui Zhou, Yap Peiling, Zhang, Li-Ping, Wang, Jian, Zhou, Xiao-Nong, Wu, Fang-Wei, Chen Ran, Du, Zun-Wei, Zhang Li-Ping, Xue-Zhong Wang, Zhou Xiao-Nong, Wang, Xue-Zhong, Zhou Hui, Steinmann, Peter, Li-Ping Zhang, Peiling Yap, Chen, Ran, Jian Wang, Wu Fang-Wei, Wang Xue-Zhong   +32 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Physiological criteria of functional fitness and determinants of physical work capacity of highly skilled wrestlers

Physical Education of Students, 2020
Background and Study Aim. The objective of the work is to study the key factors of highly skilled wrestler fitness structure determining the level of their functional state and physical work capacity at the stage of maximum realization of individual ...
Oleksandr Pryimakov, Sergii Iermakov, Jerzy Eider, Stanislav Prysiazhniuk, Natalija Mazurok   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

2026 ACSM Fitness Trends and Kinesiological Implications for the Korean Fitness Market [PDF]

The Asian Journal of Kinesiology
OBJECTIVES To analyze the primary fitness trends identified in the 2026 ACSM Worldwide Fitness Trends from a kinesiology perspective and to evaluate their applicability to the structural and sociocultural context of the Korean fitness market.
Ju-Hyoung Park, Seong-Eon Kim
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source