Results 61 to 70 of about 3,570,719 (299)

Fitness functions for RNA structure design

Nucleic Acids Research, 2022
Abstract An RNA design algorithm takes a target RNA structure and finds a sequence that folds into that structure. This is fundamentally important for engineering therapeutics using RNA. Computational RNA design algorithms are guided by fitness functions, but not much research has been done on the merits of these functions.
Max Ward, Eliot Courtney, Elena Rivas
openaire   +2 more sources

Measuring the Impact of COVID-19 on Young Adult Functional Capacity: A Comparative Study of Walking and Step Endurance Tests

Physical Education Theory and Methodology
Objectives. This study aimed to evaluate and compare the functional capacity of young adults recovering from COVID-19 using the 6-Minute Walk Test (6MWT) and 2-Minute Step Test (2MST), focusing on cardiovascular parameters, and to examine correlations ...
Patchareeya Amput, Arunrat Srithawong, Sinthuporn Maharan, Puttipong Poncumhak, Patcharin Phrompao, Eakarach Wongsaya, Tichanon Promsrisuk, Sahachat Aueyingsak   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Aptidão física funcional de idosos praticantes de hidroginástica

Revista Brasileira de Geriatria e Gerontologia
O estudo teve como objetivo verificar a aptidão física funcional de idosos praticantes de hidroginástica. A amostra foi constituída por 18 mulheres idosas, com idade média de 65,5±5,84 praticantes das aulas de hidroginástica do Centro de Excelência em ...
Rui Gonçalves Marques Elias, Eliane Cristina de Andrade Gonçalves, Augusto César Ferreira de Moraes, Cibelly Formaggio Moreira, Carlos Alexandre Molena Fernandes   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Non-Parametric Function Fitting

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1972
Summary In this note we consider the problem of fitting a general functional relationship between two variables. We require only that the function to be fitted is, in some sense, “smooth”, and do not assume that it has a known mathematical form involving only a finite number of unknown parameters.
Priestley, M. B., Chao, M. T.
openaire   +2 more sources

Lifetime Fitness Protein Powder Reviews

, 2021
Lifetime Fitness Protein supplement decisions will assume a colossal part in how effective you'll be at boosting your digestion and accomplishing the benefits referenced previously Our nourishment approach at Life Time is fixated on picking healthy ...
Lifetime Fitness Protein
core   +1 more source

Kansas Fitness Week, May 1-9, 1982 : fitness is for everybody

, 1982
"Sponsored by the Governor's Council on Fitness"--Page 6Fitness is for Every Body -- Kansas Fitness Week May 1-9, 1982 -- Celebrate Fitness -- Governor's Cup Running Events -- Capitol Runs -- Regional Runs -- Guidelines to Success -- 1981 Project Sites --
Governor's Council on Fitness
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source