Results 81 to 90 of about 3,570,719 (299)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The ethical beliefs and behaviours of Victorian fitness professionals [PDF]

, 2000
A survey based on those employed by Petitpas, Brewer, Rivera, and Van Raalte (1994), Pope, Tabachnick, and Keith-Spiegel (1987), Tabachnick, Keith-Spiegel, and Pope (1991), and Pope and Vetter (1992) was used to investigate the ethical beliefs and ...
Andersen, Mark B, Mark B. Andersen, Hemphill, Dennis, Andrew Dawson, Andersen, Mark B., Dawson, Andrew, Dennis Hemphill, Mark B Andersen   +7 more
core   +1 more source

Effect of modified Khon dance performance on functional fitness in older Thai persons [PDF]

Journal of Health Research, 2018
Purpose - Aging population is on the rise around the world. Strategies to improve quality of life in this population are being implemented. Exercise is one of those strategies that has been proven to be effective as it produces many health benefits.
Ladawan Chutimakul, Suchitra Sukonthasab, Thanomwong Kritpet, Chanai Vannalee   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Probability in Biology: The Case of Fitness [PDF]

, 2012
I argue that the propensity interpretation of fitness, properly understood, not only solves the explanatory circularity problem and the mismatch problem, but can also withstand the Pandora’s box full of problems that have been thrown at it.
Millstein, Roberta L.
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Fitness test profiles in children aged 8-12 years old in Granada (Spain) [PDF]

, 2011
The aim of this study was to determine the effects of physical education in body composition and health-related fitness among boys and girls aged 8 to 12 years old in Granada (Spain) in a longitudinal, randomized study of 5 months.
Ricardo López, Francisco Javier Rojas, López García, Ricardo, Concepción Suárez-Llorca, Andreu Cabrera, Eliseo, Eliseo Andreu-Cabrera, Cepero González, Mar, López, Ricardo, Suárez Llorca, Concepción, Rojas Ruiz, Francisco Javier, Mar Cepero, Andreu-Cabrera, Eliseo   +11 more
core   +1 more source

Early functional improvement after stroke correlates with cardiovascular fitness

Kaohsiung Journal of Medical Sciences, 2018
Cardiovascular fitness exerts directly beneficial effects on functional and cognitive outcomes in patients of chronic stroke. However, the effect of early rehabilitation on cardiovascular function has not yet been thoroughly examined.
Chun-Kai Chen, Mao-Hsiung Huang, Wen-Lung Liang, Ruey-Tay Lin, Suh-Hang H. Juo   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Differences in physical-fitness test scores between actively and passively recruited older adults: consequences for norm-based classification [PDF]

, 2002
This study investigated differences in physical-fitness test scores between actively and passively recruited older adults and the consequences thereof for norm-based classification of individuals.
van Heuvelen, M.J.G., Stevens, M., Stevens, M.; id_orcid, Kempen, G.I.J.M.   +3 more
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