Results 111 to 120 of about 8,902,876 (363)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Assessing the Demand for a Functional Food Product: Is There Cannibalization in the Orange Juice Category? [PDF]

The demand for functional foods has increased notably in recent years due to growing consumer interest in diet and health issues. Currently, the food industry is introducing many types of new food products with functional attributes.
Capps, Oral, Jr., Nayga, Rodolfo M., Jr., Yuan, Yan   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Hyperoside ameliorates depression-like behavior in ovariectomized mice

Applied Biological Chemistry
The physiological changes caused by the decline in estrogen levels due to menopause are linked to an increased risk of depression. This study investigated the antidepressant effects of hyperoside (HYP), a natural flavonol glycoside, and its associated ...
Kyung Hee Hong, Jonghoon Jung, Minji Kim, Min Young Um   +3 more
doaj   +1 more source

Fermented Porphyra haitanensis polysaccharides inhibit the degranulation of mast cell and passive cutaneous anaphylaxis

Food & Medicine Homology
Polysaccharides derived from Porphyra haitanensis exhibit a range of biological activities. However, they are characterized by high molecular weight and low utilization rates.
Zhen Cheng, Shao-Han Wang, Ling-Ying Li, Yu-Chen Zhou, Cong-Yi Zhang, Hong Liu, Tzu-Ming Pan, Guang-Ming Liu, Qing-Mei Liu   +8 more
doaj   +1 more source

Polyphenols from Acorn Leaves (Quercus liaotungensis) Protect Pancreatic Beta Cells and Their Inhibitory Activity against α-Glucosidase and Protein Tyrosine Phosphatase 1B

Molecules, 2018
Acorn leaves, which possess potential pharmacologic effects, are traditionally consumed as food in China. Phytochemical investigations of acorn leaves yielded one new and 25 known polyphenols, and their structures were identified by extensive ...
Jing Xu, Xude Wang, Jiayin Yue, Yuanyuan Sun, Xiaoshu Zhang, Yuqing Zhao   +5 more
doaj   +1 more source

The acceptance of functional foods in Denmark, Finland and the United States: A study of consumers' conjoint evaluations of the qualities of functional foods and perceptions of general health factors and cultural values. [PDF]

Functional foods is a relatively new concept covering food products enriched with various kinds of (natural) substances (eg vitamins, minerals or probiotic cultures) or modified so as to provide consumers with an additional physiological benefit presumed
Bech-Larsen , Tino, Grunert, Klaus. G., Poulsen, Jacob   +2 more
core  

Xoconostle fruit (Opuntia matudae Scheinvar cv. Rosa) by-products as potential functional ingredients [PDF]

, 2015
There is a lack of information on the potential use of xoconostle cultivars as sources of antioxidants for food, pharmaceutical and colorant industries.
Barros, Lillian, Ferreira, Isabel C.F.R., Morales, Patricia, Ramírez-Moreno, Esther, Santos-Buelga, Celestino   +4 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Revisiting Barriers to Trade: Do Foregone Health Benefits Matter? [PDF]

This paper examins the question of revisiting the imposition of existing trade barriers in one case of an evolving marketplace – when a traditional food product is altered to provide, or discovered to have, human health benefits that increases their ...
Kerr, William A., Zhang, Sidi
core   +1 more source