Results 71 to 80 of about 2,126,896 (294)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
System Dynamic Approach to Assessing New Product Introduction: The Case of Functional Foods in the United States [PDF]
Health care costs particularly those associated with chronic health conditions such as cancer have been significantly increasing for both individuals and governments in the past decades, prompting the demand for preventative medical initiatives, such as ...
Amanor-Boadu, Vincent, Ross, Kara L.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Functional food consumption in Germany: A lifestyle segmentation study [PDF]
Due to increasing health consciousness among consumers, there is an ever‐growing demand for food and beverages with health‐improving components. Not only ‘light’ and low fat products are in demand, but increasingly so‐called well‐being products and food ...
Franz, Annabell, Nowak, Beate
core
Hyperoside ameliorates depression-like behavior in ovariectomized mice
Applied Biological ChemistryThe physiological changes caused by the decline in estrogen levels due to menopause are linked to an increased risk of depression. This study investigated the antidepressant effects of hyperoside (HYP), a natural flavonol glycoside, and its associated ...
Kyung Hee Hong +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Much Ado about Nothing?- The Influence of Functional Food on Profitability of German Food Industry. [PDF]
Product innovation is a competitive strategy in food industry. Successful product development management is a key determinant of a firm?s performance.
Wittkopp, Antje
core
Assessing the response of nematode communities to climate change-driven warming : a microcosm experiment [PDF]
, 2013 Biodiversity has diminished over the past decades with climate change being among the main responsible factors. One consequence of climate change is the increase in sea surface temperature, which, together with long exposure periods in intertidal areas ...
Gingold, Ruth +2 more
core +3 more sources
European Journal of Clinical Nutrition, 2010 Michael A. Rogers, Paul A. Spagnuolo
openaire +3 more sources
Food & Medicine HomologyPolysaccharides derived from Porphyra haitanensis exhibit a range of biological activities. However, they are characterized by high molecular weight and low utilization rates.
Zhen Cheng +8 more
doaj +1 more source