Results 231 to 240 of about 1,597,523 (269)
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DNA Methylation and Gene Function
Science, 1980In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive.
A, Razin, A D, Riggs
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Gene trapping and functional genomics
Trends in Genetics, 1997Classical genetics depends upon investigation of function by random destruction with little information on structure. Modern mapping using random polymorphisms, cloning and sequencing investigates structure without function. The genome projects with their rapid gene discovery are, however, redefining classical genetic approaches.
M J, Evans, M B, Carlton, A P, Russ
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Analysis of Gene Function in the Retina
2008The Retina is a good model system for studies of neural development and disease because of its simplicity and accessibility. To analyze gene function rapidly and conveniently, we developed an electroporation technique in mice and rats for use in vivo and in vitro.
Takahiko, Matsuda, Constance L, Cepko
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BRCA1 gene: function and deficiency
International Journal of Clinical Oncology, 2017The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1.
Miho, Takaoka, Yoshio, Miki
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Unraveling the Function of the Retinoblastoma Gene
1993Publisher Summary Retinoblastoma is a childhood ocular tumor that can be either heritable or nonheritable. The cellular origin of retinoblastoma is a precursor of the neuroepithelial cells of the developing retina. The disease is correlated with inactivation of both alleles of a gene, RB1 , which is located on chromosome 13 band q14.2.
E, Zacksenhaus +7 more
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Regucalcin Evolution and Gene Function
2020The ability to synthetize ascorbic acid has been lost multiple times in animals always due to mutations in the terminal gene (GULO) of the Vitamin C synthesis pathway. This suggests that the other genes of the pathway perform other essential functions besides participating in the synthesis of Vitamin C.
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Functional misassignment of genes
Nature Biotechnology, 2001S S, Jeong, R, Chen
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