Results 261 to 270 of about 2,588,001 (311)

BRCA1 gene: function and deficiency

International Journal of Clinical Oncology, 2017
The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1.
Miho, Takaoka, Yoshio, Miki
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Gene trapping and functional genomics

Trends in Genetics, 1997
Classical genetics depends upon investigation of function by random destruction with little information on structure. Modern mapping using random polymorphisms, cloning and sequencing investigates structure without function. The genome projects with their rapid gene discovery are, however, redefining classical genetic approaches.
M J, Evans, M B, Carlton, A P, Russ
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Attributing functions to genes and gene products

Trends in Biochemical Sciences, 2011
A major focus of modern biochemical, biophysical and cell biological research is the attribution of function to elements of structure: gene products, genes and higher-order cellular structures. Misunderstandings and controversies can arise in connection with such assignments, in part because of the logical complexity inherent in the relating of ...
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DNA Methylation and Gene Function

Science, 1980
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive.
A, Razin, A D, Riggs
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Functional Gene Variants of CYP3A4

Clinical Pharmacology & Therapeutics, 2014
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound-metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and--in rare cases--lead to loss of activity, implying tremendous consequences for ...
A N, Werk, I, Cascorbi
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Gene Function Analysis

2017
In Chap. 5, a granular self-organizing network for clustering and a methodology for gene ranking using the concept of granularity are described.
Sankar K. Pal, Shubhra S. Ray, Avatharam Ganivada   +2 more
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Analysing gene function after duplication

BioEssays, 2001
AbstractAfter gene duplication, mutations cause the gene copies to diverge. The classical model predicts that these mutations will generally lead to the loss of function of one gene copy; rarely, new functions will be created and both duplicate genes are conserved.
T, Massingham, L J, Davies, P, Liò
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Termites as Functional Gene Resources

Recent Patents on Biotechnology, 2009
Termites (Dictyoptera, Isoptera) comprise a complex assemblage of diverse species, roughly divided into so-called lower and higher termites. Lower termites harbor a dense and diverse population of prokaryotes and flagellated protists (single-cell eukaryotes) in their gut.
Toru, Matsui, Gaku, Tokuda, Naoya, Shinzato   +2 more
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Imprinted genes and neuroendocrine function

Frontiers in Neuroendocrinology, 2008
Imprinted genes are monoallelically expressed in a parent-of-origin dependent manner. Whilst the full functional repertoire of these genes remains obscure, they are generally highly expressed in the brain and are often involved in fundamental neural processes.
William, Davies, Phoebe M Y, Lynn, Dinko, Relkovic, Lawrence S, Wilkinson   +3 more
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Wilms' tumour gene and function

Current Opinion in Genetics & Development, 1993
The Wilms' tumour gene, WT1, encodes a protein with four zinc fingers that is probably a transcription factor. In humans, WT1 mutations can lead to childhood kidney tumours and to developmental defects of the kidney and gonad. The WT1 gene may have a role in the mesenchyme to epithelial switch in a range of mesodermally derived tissues.
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