Results 71 to 80 of about 56,894 (219)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The EMBO JournalThe distribution of N6-methyladenosine (m6A) controls its substrate RNA fate, playing key roles in various biological processes. However, the mechanism underlying site-selective m6A deposition of RNAs, especially in the start codon regions, and the role ...
Tian-Qi Chen +13 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
On knowing a gene: A distributional hypothesis of gene function
Cell SystemsAs words can have multiple meanings that depend on sentence context, genes can have various functions that depend on the surrounding biological system. This pleiotropic nature of gene function is limited by ontologies, which annotate gene functions without considering biological contexts.
Jason J, Kwon +4 more
openaire +2 more sources
Function and specificity of Hox genes
The International Journal of Developmental Biology, 2009 The Hox genes specify different structures along the anteroposterior axis of bilaterians. They code for transcription factors including a conserved domain, the homeodomain, that binds DNA. The specificity of Hox function is determined by each gene controlling the expression of different groups of downstream genes.
Foronda, David +3 more
openaire +4 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
A Proposal for a Gene Functions Wiki [PDF]
, 2006 Large knowledge bases integrating different domains can provide a foundation for new applications in biology such as data mining or automated reasoning The traditional approach to the construction of such knowledge bases is manual and therefore extremely time consuming The ubiquity of the internet now makes large-scale community collaboration for the ...
Robert Hoehndorf +6 more
openaire +1 more source
Chinese Medical Journal. The tumor immune microenvironment (TIME) plays a pivotal role in tumor initiation, progression, and therapeutic response, and is closely associated with long-term treatment efficacy.
Dongping Chen +5 more
doaj +1 more source
Metabolic modulation of redox state confounds fish survival against Vibrio alginolyticus infection
Microbial Biotechnology, 2020 Summary Vibrio alginolyticus threatens both humans and marine animals, but hosts respond to V. alginolyticus infection is not fully understood. Here, functional metabolomics was adopted to investigate the metabolic differences between the dying and ...
Qi‐yang Gong +5 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source