Results 131 to 140 of about 3,788,624 (254)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in Streptococcus pneumoniae

Microbiology Spectrum
In all living cells, molecular chaperones and ATP-dependent proteases are essential for protein homeostasis. The ClpXP protease is a chaperone-protease complex conserved between bacteria and mitochondria.
Viktor H. Mebus, Supradipta De, Larissa M. Busch, Manuela Gesell Salazar, Rabea Schlüter, Uwe Völker, Sven Hammerschmidt, Dorte Frees   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Genetics and functional genomics of Familial Hypercholesterolemia

, 2017
Genetics and functional genomics of Familial Hypercholesterolemia.N/
Bourbon, Mafalda
core  

Functional genomics in sand fly–derived promastigotes: Main findings.

, 2019
Functional genomics in sand fly–derived promastigotes: Main findings.
Maribel Jiménez (22374), Ana Alonso, Ana Alonso (673057), Peter J. Myler (244412), Peter J. Myler, Pedro J. Alcolea (553038), Ricardo Molina (505031), Maribel Jiménez, Vicente Larraga (238914), Ricardo Molina, Pedro J. Alcolea, Vicente Larraga   +11 more
core   +1 more source

Coordination of the Fe-S cluster biogenesis network by the sRNA RyhB in E. coli

RNA Biology
Iron (Fe) plays critical roles as enzyme cofactor involved in key biological processes but can also lead to toxicity by catalysing the formation of highly damaging reactive oxygen species.
Karine Prévost, Carlos Daniel Vega Valle, Marie-Hélène Normand, Aura-Lee Béliveau-Caron, Sarah Poirier, David Lalaouna, Thierry Chénard, Eric Massé   +7 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Functional Genomics in Psoriasis

International Journal of Molecular Sciences
Psoriasis is an autoimmune cutaneous condition that significantly impacts quality of life and represents a burden on society due to its prevalence. Genome-wide association studies (GWASs) have pinpointed several psoriasis-related risk loci, underlining the disease’s complexity.
Stefano Rossi, Ellie Louise Richards, Gisela Orozco, Stephen Eyre   +3 more
openaire   +2 more sources

Leveraging Functional Genomics for Understanding Beef Quality Complexities and Breeding Beef Cattle for Improved Meat Quality

Consumer perception of beef is heavily influenced by overall meat quality, a critical factor in the cattle industry. Genomics has the potential to improve important beef quality traits and identify genetic markers and causal variants associated with ...
Maryam Mahmoodi, Meng Zhao, Jing Tian, Xiao Wang, Sina Esmailizadeh Koshkoiyeh, Rugang Tian, Mahla Saminzadeh, Hui Li, Yuan Li, Ali Esmailizadeh   +9 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source