Results 121 to 130 of about 3,788,624 (254)

Resistome and microbiome-immune interactions in an Eastern European population with high antibiotic use

Microbiology Spectrum
The gut microbiome influences host health, affecting gastrointestinal, metabolic, immune, cardiovascular, and neurological functions. A balanced microbiome is associated with favorable health outcomes. However, excessive antibiotic use and dietary habits
Bogdan Mirăuță, Anca-Lelia Riza, Ioana Streata, Andrei Pirvu, Stefania Dorobantu, Adina Dragos, Marius Surleac, Mihai G. Netea   +7 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Effect of Altitude on the Agronomic Performance of Four Improved Maize Varieties Under Dissemination in Côte d’Ivoire

International Journal of Agronomy
Maize is a staple crop for millions, yet its production in Côte d’Ivoire remains below potential despite advances in improved varieties. Environmental conditions, including altitude, potentially influence maize performance, but data on altitude’s effect ...
Lassana Tioté, Yaya Nadiala Coulibaly, Yao Raymond Koffi   +2 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Analysis of CR1 Repeats in the Zebra Finch Genome [PDF]

Journal of Systemics, Cybernetics and Informatics, 2013
Most bird species have smaller genomes and fewer repeats than mammals. Chicken Repeat 1 (CR1) repeat is one of the most abundant families of repeats, ranging from ~133,000 to ~187,000 copies accounting for ~50 to ~80% of the interspersed repeats in the ...
George E. Liu, Yali Hou, Twain Brown
doaj  

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Three modified human IPSC lines containing mutations in the distal DEHMBA associated locus of the SRCAP gene

Stem Cell Research
We modified an existing human iPSC line (MHHi001-A), using CRISPR/Cas9, to introduce heterozygous frameshift mutations in a locus of the SRCAP gene that is associated with the DEHMBA disease (OMIM 619595).
Johannes Rhode, Lisa Hagenau, Stephanie Edwards, Falk F.R. Buettner, Ana Tzvetkova, Lars R. Jensen, Andreas W. Kuss   +6 more
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Precision and Functional Genomics [PDF]

Mammalian Genome, 2020
Steve D M, Brown, Joseph H, Nadeau
openaire   +2 more sources

Integrating diverse functional genomics data improves enhancer prediction.

, 2014
(A) Considering functional genomics features from contexts and assays not directly associated with developmental enhancer activity (All Functional Genomics and Relevant Functional Genomics) improves the identification of developmental enhancers (p = 9.2E-
Rebecca M. Truty (158316), Nadav Ahituv (34361), Katherine S. Pollard (14217), Dennis Kostka (275330), John A. Capra (155231), Genevieve D. Erwin (589074), Karl K. Murphy (589075), Nir Oksenberg (102535)   +7 more
core   +1 more source