Results 141 to 150 of about 400,284 (267)

Snowwhite: a rapid genetic tool for sweet potato functional genomics. [PDF]

Plant Physiol
Peng K, Bai Y, Dai Z, Shang M, Zhang J, Zhai H, Gao S, Zhao N, Liu Q, He S, Zhang H.   +10 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

An AI-powered knowledge hub for potato functional genomics. [PDF]

Plant Commun
Li J, Jia Y, Li F, Su X, Luo J, Dong Y, Sun C, Cui Q, Wang L, Li A, Shang Y, Huang S, Zhu Y, Jia Y.   +13 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A submission checklist to improve transparency and replicability of functional genomics data analyses. [PDF]

J Biol Chem
Hepperla AJ, Hardison RC, Colbran RJ, Strahl BD, Simon JM.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Functional Genomics Screening in <i>Chlamydomonas reinhardtii</i> Maps the Genetic Landscape of Tolerance to Paraquat and Diuron. [PDF]

Environ Sci Technol
Godec T, Bleker C, Stare K, Lukan T, Levak V, Tušek Žnidarič M, Betz A, Kosjek T, van Midden KP, Klemenčič M, Trenti F, Guella G, Sepčić K, Fauser F, Patena W, Jonikas MC, Kerenčič M, Eleršek T, Pietri M, Rodet T, Bren U, Jukić M, Lešnik S, Županič A.   +23 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Pre-training genomic language model with variants for better modeling functional genomics. [PDF]

NPJ Artif Intell
Liu T, Zhang X, Lin J, Pinello L, Ying R, Zhao H.   +5 more
europepmc   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source