Results 31 to 40 of about 3,788,624 (254)

Induction of central host signalling kinases during pneumococcal infection of human THP-1 cells

Frontiers in Cellular and Infection Microbiology, 2016
Streptococcus pneumoniae is a widespread colonizer of the mucosal epithelia of the upper respiratory tract of human. However, pneumococci are also responsible for numerous local as well as severe systemic infections, especially in children under the age ...
Thomas Peter Kohler, Annemarie eScholz, Delia eKiachludis, Sven eHammerschmidt   +3 more
doaj   +1 more source

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis

Frontiers in Microbiology
A sudden increase in temperature triggers Bacillus subtilis to activate expression of stress-specific heat shock proteins of the CtsR (class three stress gene repressor) regulon to withstand the adverse conditions.
Marco Harms, Chelsea Kaden, Larissa M. Busch, Vishnu M. Dhople, Ulf Gerth, Manuela Gesell Salazar, Stephan Michalik, Zhanetta Zhatarova, Zhanetta Zhatarova, Uwe Völker, Alexander Reder   +10 more
doaj   +1 more source

Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08

mSphere, 2018
Streptococcus pneumoniae two-component regulatory systems (TCS) enable adaptation and ensure its maintenance in host environments. This study deciphers the impact of TCS08 on pneumococcal gene expression and its role in metabolic and pathophysiological ...
Alejandro Gómez-Mejia, Gustavo Gámez, Stephanie Hirschmann, Viktor Kluger, Hermann Rath, Sebastian Böhm, Franziska Voss, Niamatullah Kakar, Lothar Petruschka, Uwe Völker, Reinhold Brückner, Ulrike Mäder, Sven Hammerschmidt   +12 more
doaj   +1 more source

Generation of an iPSC line (UMGWi001-B) from a patient with Floating-Harbor Syndrome (FLHS) carrying a heterozygous SRCAP mutation (p.Arg2444)

Stem Cell Research, 2020
Floating-Harbor syndrome (FLHS) is a rare genetic disease caused by mutations in the SRCAP gene. Here, we generated an induced pluripotent stem cell line from gingival fibroblasts of a male patient with a heterozygous mutation in exon 34 of the SRCAP ...
M. Franz, L. Hagenau, R. Koch, S. Neubauer, B. Nowack, A. Tzvetkova, L.R. Jensen, A.W. Kuss   +7 more
doaj   +1 more source

Clinical significance of matrix metalloproteinase-9 in Fragile X Syndrome

Scientific Reports, 2022
High plasma matrix metalloproteases-9 (MMP-9) levels have been reported in Fragile X Syndrome in a limited number of animal and human studies. Since the results obtained are method-dependent and not directly comparable, the clinical utility of MMP-9 ...
Asma Laroui, Luc Galarneau, Armita Abolghasemi, Sérine Benachenhou, Rosalie Plantefève, Fatima Zahra Bouchouirab, Jean François Lepage, François Corbin, Artuela Çaku   +8 more
doaj   +1 more source

Generation of two iPSC lines (MHHi001-A-12 and MHHi001-A-13) carrying biallelic truncating mutations at the 3′-end of SRCAP using CRISPR/Cas9

Stem Cell Research, 2023
Non-Floating Harbour Syndrome (FLHS) neurodevelopmental disorder (NDD) is a recently described disorder caused by mutations in certain regions of the SRCAP gene.
J. Rhode, L. Hagenau, J. Beimdiek, R. Ullmann, F. Hossain, A. Tzvetkova, L.R. Jensen, A.W. Kuss   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

pTripleTREP – A vector for tightly controlled expression and purification of virulence factors in Staphylococcus aureus

Microbial Cell Factories
Background Recombinant proteins facilitate and contribute to detailed studies of the virulence mechanisms and pathophysiology of the major human pathogen Staphylococcus aureus. Of particular interest are secreted virulence factors.
Hannes Wolfgramm, Christopher Saade, Marco Harms, Larissa M. Busch, Josephine Lange, Maximilian Schedlowski, Kristin Surmann, Manuela Gesell Salazar, Christian Hentschker, Leif Steil, Stephan Michalik, Uwe Völker, Alexander Reder   +12 more
doaj   +1 more source

Global quantitative proteome analysis of a multi-resistant Klebsiella pneumoniae strain

Frontiers in Microbiology
Klebsiella pneumoniae is a critical nosocomial pathogen with a rising incidence in antibiotic resistance worldwide. Multidrug-resistant strains of K. pneumoniae pose a major health threat, particularly to immunosuppressed and elderly patients.
Marie-Sofie Illenseher, Marie-Sofie Illenseher, Christian Hentschker, Manuela Gesell Salazar, Larissa Milena Busch, Lisa Zierke, Alexander Reder, Stephan Michalik, Uwe Völker, Sven Hammerschmidt, Kristin Surmann   +10 more
doaj   +1 more source

Trypanosoma cruzi specific mRNA amplification by in vitro transcription improves parasite transcriptomics in host-parasite RNA mixtures

BMC Genomics, 2017
Background Trypanosomatids are a group of protozoan parasites that includes the etiologic agents of important human illnesses as Chagas disease, sleeping sickness and leishmaniasis.
Rafael Luis Kessler, Daniela Parada Pavoni, Marco Aurelio Krieger, Christian Macagnan Probst   +3 more
doaj   +1 more source