Results 21 to 30 of about 400,284 (267)

Clinical Functional Genomics [PDF]

Cancers, 2021
Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the genome leading to expression of particular phenotypes.
Seren Carpenter, R. Conlan
openaire   +4 more sources

Functional Genomic Characterization of Cancer Genomes [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2016
International efforts to sequence cancer genomes now provide an overview of the major genetic alterations that occur in most human cancers. These studies have identified many highly recurrent alterations in specific cancer subtypes but have also identified mutations that occur at lower frequency and unstudied variants of known cancer-associated genes ...
Thomas P, Howard, Francisca, Vazquez, Aviad, Tsherniak, Andrew L, Hong, Mik, Rinne, Andrew J, Aguirre, Jesse S, Boehm, William C, Hahn   +7 more
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Generation of two iPSC lines (MHHi001-A-12 and MHHi001-A-13) carrying biallelic truncating mutations at the 3′-end of SRCAP using CRISPR/Cas9

Stem Cell Research, 2023
Non-Floating Harbour Syndrome (FLHS) neurodevelopmental disorder (NDD) is a recently described disorder caused by mutations in certain regions of the SRCAP gene.
J. Rhode, L. Hagenau, J. Beimdiek, R. Ullmann, F. Hossain, A. Tzvetkova, L.R. Jensen, A.W. Kuss   +7 more
doaj   +1 more source

Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ

Current Research in Microbial Sciences
Mouse-adapted Staphylococcus aureus strains have become increasingly relevant in infection research thanks to their ability to better recapitulate clinical infection dynamics in mouse models.
Hannes Wolfgramm, Larissa Milena Busch, Jöran Tebben, Henry Mehlan, Lisa Hagenau, Thomas Sura, Tilly Hoffmüller, Elisa Bludau, Manuela Gesell Salazar, Alexander Reder, Stephan Michalik, Leif Steil, Kristin Surmann, Ulrike Mäder, Silva Holtfreter, Uwe Völker   +15 more
doaj   +1 more source

Clinical significance of matrix metalloproteinase-9 in Fragile X Syndrome

Scientific Reports, 2022
High plasma matrix metalloproteases-9 (MMP-9) levels have been reported in Fragile X Syndrome in a limited number of animal and human studies. Since the results obtained are method-dependent and not directly comparable, the clinical utility of MMP-9 ...
Asma Laroui, Luc Galarneau, Armita Abolghasemi, Sérine Benachenhou, Rosalie Plantefève, Fatima Zahra Bouchouirab, Jean François Lepage, François Corbin, Artuela Çaku   +8 more
doaj   +1 more source

Requirement of ClpX for CtsR dissociation from its operator elements upon heat stress in Bacillus subtilis

Frontiers in Microbiology
A sudden increase in temperature triggers Bacillus subtilis to activate expression of stress-specific heat shock proteins of the CtsR (class three stress gene repressor) regulon to withstand the adverse conditions.
Marco Harms, Chelsea Kaden, Larissa M. Busch, Vishnu M. Dhople, Ulf Gerth, Manuela Gesell Salazar, Stephan Michalik, Zhanetta Zhatarova, Zhanetta Zhatarova, Uwe Völker, Alexander Reder   +10 more
doaj   +1 more source

Pneumococcal Metabolic Adaptation and Colonization Are Regulated by the Two-Component Regulatory System 08

mSphere, 2018
Streptococcus pneumoniae two-component regulatory systems (TCS) enable adaptation and ensure its maintenance in host environments. This study deciphers the impact of TCS08 on pneumococcal gene expression and its role in metabolic and pathophysiological ...
Alejandro Gómez-Mejia, Gustavo Gámez, Stephanie Hirschmann, Viktor Kluger, Hermann Rath, Sebastian Böhm, Franziska Voss, Niamatullah Kakar, Lothar Petruschka, Uwe Völker, Reinhold Brückner, Ulrike Mäder, Sven Hammerschmidt   +12 more
doaj   +1 more source

The Two-Component System 09 Regulates Pneumococcal Carbohydrate Metabolism and Capsule Expression

Microorganisms, 2021
Streptococcus pneumoniae two-component regulatory systems (TCSs) are important systems that perceive and respond to various host environmental stimuli. In this study, we have explored the role of TCS09 on gene expression and phenotypic alterations in S ...
Stephanie Hirschmann, Alejandro Gómez-Mejia, Ulrike Mäder, Julia Karsunke, Dominik Driesch, Manfred Rohde, Susanne Häussler, Gerhard Burchhardt, Sven Hammerschmidt   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Functional genomics in Spiralia

Briefings in Functional Genomics, 2023
Abstract Our understanding of the mechanisms that modulate gene expression in animals is strongly biased by studying a handful of model species that mainly belong to three groups: Insecta, Nematoda and Vertebrata. However, over half of the animal phyla belong to Spiralia, a morphologically and ecologically diverse animal clade with many ...
Francisco M Martín-Zamora, Billie E Davies, Rory D Donnellan, Kero Guynes, José M Martín-Durán   +4 more
openaire   +3 more sources