Results 21 to 30 of about 3,788,624 (254)
Association of lipid rafts cholesterol with clinical profile in fragile X syndrome
Scientific Reports, 2022 Fragile X syndrome (FXS) is the most prevalent monogenic cause of intellectual disability and autism spectrum disorder (ASD). Affected individuals have a high prevalence of hypocholesterolemia, however, the underlying mechanisms and the clinical ...
Amanda Toupin +7 more
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Functional genomics in gastroenterology [PDF]
Gut, 2000 Identification of the DNA structure as a double stranded helix consisting of two nucleotide chain molecules was a milestone in modern molecular biology. This discovery has lead to a rapidly accumulating body of genomic information. The dramatic developments in genetic analysis during the past decade have placed genomics at the forefront of life science
S, Schreiber +3 more
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UBB pseudogene 4 encodes functional ubiquitin variants
Nature Communications, 2020 Ubiquitin pseudogenes are present in many organisms but whether they encode functional proteins has remained unclear. Here, the authors show that human UBB pseudogene 4 produces ubiquitin variants with amino acid compositions and cellular functions that ...
Marie-Line Dubois +13 more
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Communications Biology, 2023 Uptake of obligate intracellular bacterial pathogens into mammalian epithelial cells is critically dependent on modulation of the host’s endocytic machinery.
Dominik Spona +3 more
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TIE-UP-SIN: A Method for Enhanced Identification of Protein–Protein Interactions
Bio-ProtocolProtein–protein interactions (PPIs) govern nearly all aspects of cellular physiology, yet identifying these interactions under native conditions remains challenging.
Maximilian Schedlowski +9 more
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Functional genomics of intracellular bacteria
, 2013 During the genomic era, a large amount of whole-genome sequences accumulated, which identified many hypothetical proteins of unknown function. Rapidly, functional genomics, which is the research domain that assign a function to a given gene product, has ...
Greub, Gilbert +3 more
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Comparative genomics of Arabidopsis and maize: prospects and limitations [PDF]
, 2002 Brendel V, Kurtz S, Walbot V. Comparative genomics of Arabidopsis and maize: prospects and limitations. Genome Biology. 2002;3(3): reviews1005.1.The completed Arabidopsis genome seems to be of limited value as a model for maize genomics.
Walbot, Virginia +2 more
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Caenorhabditis elegans functional genomics: omic resonance.
, 2004 The nematode Caenorhabditis elegans is widely used as a model organism for studying many fundamental aspects of development and cell biology, including processes underlying human disease. The genome of C.
Merry, Alyce +3 more
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Application of Functional Genomics for Bovine Respiratory Disease Diagnostics [PDF]
, 2015 Bovine respiratory disease (BRD) is the most common economically important disease affecting cattle. For developing accurate diagnostics that can predict disease susceptibility/resistance and stratification, it is necessary to identify the molecular ...
Aswathy N. Rai +2 more
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Integrated genomic and proteomic analysis of the mouse-adapted Staphylococcus aureus strain JSNZ
Current Research in Microbial SciencesMouse-adapted Staphylococcus aureus strains have become increasingly relevant in infection research thanks to their ability to better recapitulate clinical infection dynamics in mouse models.
Hannes Wolfgramm +15 more
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