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Functional genomics of complex cancer genomes [PDF]
Nature Communications, 2022 Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities ...
Francesca Menghi, Edison T. Liu
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Genomics and Functional Genomics of Alzheimer's Disease [PDF]
Neurotherapeutics, 2022 Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease. Due to its long clinical course and lack of an effective treatment, AD has become a major public health problem in the USA and worldwide. Due to variation in age-at-onset, AD is classified into early-onset (
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Functional Genomics in Plants [PDF]
Plant Physiology, 1998 The sequencing of the first genome of a higher plant, Arabidopsis, is progressing at a rapid pace. As we are writing these words, almost one-third of the estimated 100 Mb is available in public databases, and with appropriate funding the complete genome sequence is predicted to be finished by ...
Bouchez, David, Höfte, Herman
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mSystems, 2020 Systemic and quantitative investigations of human plasma proteins (proteomics) and Staphylococcus aureus-specific antibodies (immunoproteomics) provide complementary information and hold promise for the discovery of biomarkers in Staphylococcus aureus ...
Stephan Michalik +7 more
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Genome as a Functional Program [PDF]
Lobachevskii Journal of Mathematics, 2020 We discuss a model of genome as a program with functional architecture and consider the approach to Darwinian evolution as a learning problem for functional programming. In particular we introduce a model of learning for some class of functional programs.
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Genome Projects and the Functional-Genomic Era [PDF]
Combinatorial Chemistry & High Throughput Screening, 2005 The problems we face today in public health as a result of the -- fortunately -- increasing age of people and the requirements of developing countries create an urgent need for new and innovative approaches in medicine and in agronomics. Genomic and functional genomic approaches have a great potential to at least partially solve these problems in the ...
Sauer, S., Konthur, Z., Lehrach, H.
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Enabling functional genomics with genome engineering [PDF]
Genome Research, 2015 Advances in genome engineering technologies have made the precise control over genome sequence and regulation possible across a variety of disciplines. These tools can expand our understanding of fundamental biological processes and create new opportunities for therapeutic designs.
Hilton, Isaac B., Gersbach, Charles A.
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Nongenetic functions of the genome [PDF]
Science, 2016 The nongenetic roles of the nucleus The eukaryotic cell nucleus provides a home for the genetic material and accessory proteins. As a physical entity, the nucleus also plays an important role in cell dynamics. Bustin and Misteli Review the impacts that the nucleus can have as a nongenetic force.
Michael, Bustin, Tom, Misteli
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Proceedings of the National Academy of Sciences, 1999 Complete genome sequences are providing a framework to allow the investigation of biological processes by the use of comprehensive approaches. Genome analysis also is having a dramatic impact on medicine through its identification of genes and mutations involved in disease and the elucidation of entire microbial gene sets ...
S, Fields, Y, Kohara, D J, Lockhart
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Functional Genomics with YBL036c [PDF]
The Scientific World JOURNAL, 2002 Functions of more than 2,000 genes in the Saccharomyces cerevisiae genome are still unknown. Gene YBL036c is among them. Gene YBL036c encodes a protein that is PLP (pyridoxalphosphate) dependent. Its sequence does not indicate similarity to any known protein. However, its 3D structure, including the active site residues, are almost identical to that of
Ludmilla Berenfeld +3 more
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