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Functional Heartburn: Definition and Management Strategies
Current Gastroenterology Reports, 2012Functional heartburn (FH) is a functional gastro-intestinal disorder characterized by symptoms of heartburn not related to gastro-esophageal reflux. The absence of evidence of reflux-related symptoms relies on absence of esophagitis at endoscopy (including biopsies to exclude eosinophilic esophagitis), a normal esophageal acid exposure during ...
Frank, Zerbib +3 more
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Diagnosis and Management of Functional Heartburn
American Journal of Gastroenterology, 2016Heartburn is among the most common gastrointestinal symptoms presenting to both generalist physicians and gastroenterologists. Heartburn that does not respond to traditional acid suppression is a diagnostic and therapeutic dilemma. In the era of high utilization of proton pump inhibitors, a substantial proportion of patients presenting to the ...
Christine, Hachem, Nicholas J, Shaheen
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Refractory Gastroesophageal Reflux Disease and Functional Heartburn
Gastrointestinal Endoscopy Clinics of North America, 2020This report discusses the potential mechanisms that might underlie refractory GERD and functional heartburn, and how to distinguish among those mechanisms using a systematic evaluation that includes careful medical history, endoscopy with esophageal biopsy, esophageal manometry, and esophageal multichannel intraluminal impedance-pH monitoring.
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American Journal of Gastroenterology, 2016
To the Editor: We read with interest the clinical and systematic review on diagnosis and management of functional heartburn by Christine Hachem and Nicholas J. Shaheen (1). Authors have done a remarkable job that help readers to enter patients in correct categories of disease, despite the confusing nature of the topic.
SCARINGI, STEFANO +2 more
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To the Editor: We read with interest the clinical and systematic review on diagnosis and management of functional heartburn by Christine Hachem and Nicholas J. Shaheen (1). Authors have done a remarkable job that help readers to enter patients in correct categories of disease, despite the confusing nature of the topic.
SCARINGI, STEFANO +2 more
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AGA Clinical Practice Update on Functional Heartburn: Expert Review
Gastroenterology, 2020BEST PRACTICE ADVICE 1: A diagnosis of functional heartburn should be considered when retrosternal burning pain or discomfort persists despite maximal (double-dose) proton pump inhibitor (PPI) therapy taken appropriately before meals during a 3-month period.
Ronnie Fass +2 more
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American Journal of Gastroenterology, 2011
Refractory heartburn despite acid suppression may be explained by ongoing gastroesophageal reflux disease (GERD) or functional heartburn (FH), i.e., symptoms without evidence of GERD. Impedance-pH monitoring (impedance-pH) detects acid and nonacid reflux and is useful for evaluating acid-suppressed, refractory patients.
Marcelo F, Vela +4 more
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Refractory heartburn despite acid suppression may be explained by ongoing gastroesophageal reflux disease (GERD) or functional heartburn (FH), i.e., symptoms without evidence of GERD. Impedance-pH monitoring (impedance-pH) detects acid and nonacid reflux and is useful for evaluating acid-suppressed, refractory patients.
Marcelo F, Vela +4 more
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Are functional heartburn and functional dyspepsia one disorder?
Nature Reviews Gastroenterology & Hepatology, 2010The characteristics of functional heartburn remain poorly understood. Savarino et al. have now demonstrated that functional heartburn has more in common with functional dyspepsia than with nonerosive reflux disease. This study suggests that there is substantial overlap between functional heartburn and functional dyspepsia, and possibly that these two ...
Tiberiu Hershcovici, Ronnie Fass
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The Role of Esophageal Hypersensitivity in Functional Heartburn
Journal of Clinical Gastroenterology, 2017Functional heartburn (FH) is defined as a functional esophageal disorder characterized by symptoms of chronic heartburn with no apparent correlation to acid or nonacid reflux. In addition, its symptoms persist despite the lack of organic abnormalities or inflammation, esophageal motility disorders, or metabolic disorders. Although conditions presenting
Takashi, Kondo, Hiroto, Miwa
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Gastroesophageal reflux disease-related and functional heartburn
Current Opinion in Gastroenterology, 2016Patients who continue to experience heartburn symptoms despite adequate-dose proton pump inhibitor therapy have unmet clinical needs. In this review, we focus on the most recent findings related to the mechanism of heartburn symptom generation, and on the treatment of gastroesophageal reflux disease-related and functional heartburn.The immunological ...
Hiroto, Miwa +2 more
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VISCERAL SENSITIVITY IN FUNCTIONAL HEARTBURN IS NOT ORGAN SPECIFIC
American Journal of Gastroenterology, 2003Purpose: Nomenclature and diagnostic criteria of functional GI disorders have become organ specific. Stratification by organ system may limit research and treatment algorithms and appears to be an inappropriate paradigm when the complex symptoms associated with functional disorders are catalogued.
Sheila Rodriguez-Stanley +3 more
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