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Nonerosive reflux disease and functional heartburn are clearly separate entities
European Journal of Gastroenterology & Hepatology, 2013To The Editor: We read with interest the paper by Blaga et al on the clinical and functional profiles of patients with functional heartburn (FH) (1). The Authors must be congratulated because this is one of the first studies in which the population of FH is clearly separated from the other subgroups of NERD on the basis of an objective method (i.e ...
SAVARINO, EDOARDO VINCENZO +3 more
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Functional heartburn: misdiagnosed gastroesophageal reflux or a distinct entity?
Nature Clinical Practice Gastroenterology & Hepatology, 2005For many years functional heartburn has been linked to gastroesophageal reflux disease, despite a number of characteristics that set this disorder apart. As such little has been researched regarding the physiology and treatment of patients with functional heartburn as a distinct entity.
Ronnie, Fass, Ram, Dickman
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[Functional heartburn--update 2013].
MMW Fortschritte der Medizin, 2014Functional heartburn is a frequent disease which should be considered when heartburn does not respond to proton pump inhibitor (PPI) treatment. Functional heartburn is defined in the Rome-III-criteria. Differential diagnoses like gastroesophageal reflux disease (GERD), non erosive reflux disease (NERD) and hypertensive esophagus are diagnosed employing
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Established and Emerging Treatment Options for Functional Heartburn and Chest Pain
Current Treatment Options in Gastroenterology, 2016Functional heartburn and functional chest pain of presumed esophageal origin are characterized by symptoms suggesting an esophageal origin, but negative work-up on routine investigations, including ruling out gastroesophageal reflux disease. Visceral hypersensitivity is a potentially unifying pathophysiological concept, thought to underlie these ...
Jan, Tack, Tim, Vanuytsel, Ans, Pauwels
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Update on Functional Heartburn.
Gastroenterology & hepatologyThe definition of functional heartburn has been refined over the years. It is currently described, based upon Rome IV criteria, as typical heartburn symptoms in the presence of normal upper endoscopy findings (including normal biopsies), normal esophageal pH testing, and a negative association between symptoms and reflux events. Functional heartburn is
Takahisa, Yamasaki +2 more
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Light microscopy is useful to better define NERD and functional heartburn
Gut, 2013We read with great interest the well done pathophysiological study by Woodland et al 1 showing that an impaired oesophageal mucosal integrity, expressed by low baseline impedance values, is likely due to repeated acid reflux episodes, which contribute also to slow recovery after this challenge.
Savarino E +4 more
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Functional chest pain responds to biofeedback treatment but functional heartburn does not
European Journal of Gastroenterology & Hepatology, 2012Patients with functional esophageal disorders represent a challenging treatment group. The purpose of this study was to evaluate the role of biofeedback in the treatment of patients with functional esophageal disorders.In this prospective study, patients with typical/atypical symptoms of gastroesophageal reflux disease underwent upper endoscopy and 24 ...
Michael, Shapiro +5 more
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How to differentiate non‐erosive reflux disease from functional heartburn
Journal of Digestive Diseases, 2012Heartburn is a common symptom in gastroesophageal reflux disease. Endoscopic examination can differentiate between reflux esophagitis and non‐erosive reflux disease (NERD), but not between NERD and functional heartburn. With the development of new techniques, more NERD patients could be identified among those previously diagnosed with functional ...
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Functional Heartburn: What It Is and How to Treat It
Gastrointestinal Endoscopy Clinics of North America, 2009Functional heartburn is considered one of the most common functional esophageal disorders. The disorder is more common in young women and is associated with other functional bowel disorders and psychological co-morbidity, primarily somatization. The etiology of functional heartburn remains unknown.
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Non-Erosive Reflux Disease (NERD) and Functional Heartburn
2006NERD is a real entity and its importance in the spectrum of GERD must be appreciated. Functional heartburn needs to be further differentiated as that subgroup of patients in which there appears to be no relationship between symptoms, albeit “typical” of GERD, and acid exposure.
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