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Insight into global burden of gastroesophageal reflux disease: Understanding its reach and impact. [PDF]
World J Gastrointest Pharmacol TherWickramasinghe N, Devanarayana NM.
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Current Treatment Options in Gastroenterology, 2005
Functional heartburn (FH) is a common disorder that accounts for 30% to 50% of the patients with nonerosive reflux disease. FH is composed from a heterogeneous group of patients. They primarily include the hypersensitive and the nonacid sensitive esophagus.
Ram, Dickman, Ronnie, Fass
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Functional heartburn (FH) is a common disorder that accounts for 30% to 50% of the patients with nonerosive reflux disease. FH is composed from a heterogeneous group of patients. They primarily include the hypersensitive and the nonacid sensitive esophagus.
Ram, Dickman, Ronnie, Fass
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Current Treatment Options in Gastroenterology, 2002
Functional heartburn is defined as the presence of a retrosternal burning sensation in the absence of pathologic gastroesophageal reflux. The underlying pathophysiology seems to be heterogeneous. In a subset of patients, esophageal hypersensitivity to physiologic esophageal acid exposure is involved, and this is likely to respond to intensive ...
Jan, Tack, Jozef, Janssens
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Functional heartburn is defined as the presence of a retrosternal burning sensation in the absence of pathologic gastroesophageal reflux. The underlying pathophysiology seems to be heterogeneous. In a subset of patients, esophageal hypersensitivity to physiologic esophageal acid exposure is involved, and this is likely to respond to intensive ...
Jan, Tack, Jozef, Janssens
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European Journal of Gastroenterology & Hepatology, 2013
Patients with heartburn and normal upper gastrointestinal endoscopy, normal oesophageal acid exposure, no symptom-reflux association and who fail to respond to a proton-pump inhibitor are classified as having functional heartburn (FH). This study aimed (i) to characterize the symptoms and functional abnormalities of patients with FH and (ii) to ...
Teodora, Surdea Blaga +3 more
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Patients with heartburn and normal upper gastrointestinal endoscopy, normal oesophageal acid exposure, no symptom-reflux association and who fail to respond to a proton-pump inhibitor are classified as having functional heartburn (FH). This study aimed (i) to characterize the symptoms and functional abnormalities of patients with FH and (ii) to ...
Teodora, Surdea Blaga +3 more
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Functional Heartburn: Definition and Management Strategies
Current Gastroenterology Reports, 2012Functional heartburn (FH) is a functional gastro-intestinal disorder characterized by symptoms of heartburn not related to gastro-esophageal reflux. The absence of evidence of reflux-related symptoms relies on absence of esophagitis at endoscopy (including biopsies to exclude eosinophilic esophagitis), a normal esophageal acid exposure during ...
Frank, Zerbib +3 more
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Diagnosis and Management of Functional Heartburn
American Journal of Gastroenterology, 2016Heartburn is among the most common gastrointestinal symptoms presenting to both generalist physicians and gastroenterologists. Heartburn that does not respond to traditional acid suppression is a diagnostic and therapeutic dilemma. In the era of high utilization of proton pump inhibitors, a substantial proportion of patients presenting to the ...
Christine, Hachem, Nicholas J, Shaheen
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Refractory Gastroesophageal Reflux Disease and Functional Heartburn
Gastrointestinal Endoscopy Clinics of North America, 2020This report discusses the potential mechanisms that might underlie refractory GERD and functional heartburn, and how to distinguish among those mechanisms using a systematic evaluation that includes careful medical history, endoscopy with esophageal biopsy, esophageal manometry, and esophageal multichannel intraluminal impedance-pH monitoring.
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