Results 61 to 70 of about 7,502 (199)

Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors

Annals of the New York Academy of Sciences, EarlyView.
Human bitter taste receptors are not only involved in sensing tastants within the oral cavity but also play crucial roles in internal tissues of the body. The current report identifies numerous structurally and functionally diverse steroid hormones as activators of the two human bitter taste receptors, TAS2R14 and TAS2R46.
Tatjana Lang, Francesco Ferri, Florian Ziegler, Antonella Di Pizio, Maik Behrens   +4 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Incomplete Cardia Reconstruction Cases Following Multiple Anti‐reflux Mucosectomy/Anti‐reflux Mucosal Ablation Treatments

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Introduction Anti‐reflux mucosectomy (ARMS) and anti‐reflux mucosal ablation (ARMA) are novel endoscopic treatments for proton pump inhibitor or potassium‐competitive acid blocker‐refractory gastroesophageal reflux disease. These procedures induce scarring of the artificial ulcer at the gastric cardia, which tightens the enlarged cardiac ...
Ippei Tanaka, Haruhiro Inoue, Mayo Tanabe, Yoshiaki Kimoto, Kei Ushikubo, Kazuki Yamamoto, Yohei Nishikawa, Nikko Theodore Valencia Raymundo, Kazuya Sumi   +8 more
wiley   +1 more source

Utility of the Endoscopic Pressure Study Integrated System in Identifying Silent Gastroesophageal Reflux Disease During Routine Health Check‐ups

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives The endoscopic pressure study integrated system (EPSIS) is a novel functional endoscopic modality that records intragastric pressure (IGP) waveforms during CO2 insufflation to evaluate lower esophageal sphincter (LES) function and diagnose gastroesophageal reflux disease (GERD).
Yohei Nishikawa, Haruhiro Inoue, Kazuki Yamamoto, Tomona Sakurai, Yukiko Okada, Kei Ushikubo, Kohei Shigeta, Ippei Tanaka, Satoshi Abiko, Mayo Tanabe, Takayoshi Ito, Noboru Yokoyama, Naoyuki Uragami   +12 more
wiley   +1 more source

Is Single‐Session Peroral Endoscopic Myotomy With Fundoplication Safe and Effective in Achalasia? A Systematic Review and Meta‐Analysis

DEN Open, Volume 6, Issue 1, April 2026.
This meta‐analysis of nine studies (202 patients) demonstrates that peroral endoscopic myotomy with fundoplication (POEM‐F) achieves a technical success of 94.8% and significant symptom improvement (Eckardt score reduction from 8.3 to 1.1). Post‐procedural esophagitis occurred in 20.7% and wrap integrity was preserved in 75.7% on follow‐up, supporting ...
Yusuf Kagzi, Abuzar Asif, Srinivas Reddy Puli   +2 more
wiley   +1 more source

Epidemiology of functional gastrointestinal disorders using ROME III adult questionnaire, a population based cross sectional study in Karachi-Pakistan.

PLoS ONE, 2022
ObjectiveFunctional Gastrointestinal Disorder (FGIDs) are a heterogenous group of disorders, with Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD) being the most common disorders worldwide.
Shahab Abid, Hareem Rehman, Safia Awan, Azmina Artani, Imran Siddiqui   +4 more
doaj   +1 more source

Characterization of pediatric eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis in a nationwide cohort

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 531-540, February 2026.
Abstract Objectives Nonesophageal eosinophilic gastrointestinal disorders (non‐EoE EGIDs) are rare, underrecognized inflammatory diseases of the gastrointestinal (GI) tract, especially in children. Their clinical heterogeneity and lack of specific biomarkers contribute to diagnostic delays and therapeutic challenges.
Sara Renzo, Luca Scarallo, Selene Del Vespa, Giulia Angelino, Matteo Bramuzzo, Enrico Felici, Flavio Labriola, Francesca Laganà, Lorenzo Norsa, Salvatore Oliva, Marisa Piccirillo, Elena Pozzi, Francesca Rea, Giusy Russo, Francesco Valitutti, Giovanna Zuin, Paolo Lionetti   +16 more
wiley   +1 more source

Gut Microbial Variations Associated With Proton Pump Inhibitor Use in the Boston Puerto Rican Health Study

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT Proton pump inhibitors (PPI), used to treat gastrointestinal disorders, are associated with alterations in the gut microbiome. However, this is understudied in Puerto Ricans who have unique lifestyle characteristics. Puerto Ricans, including participants of the Boston‐Puerto Rican Health Study (BPRHS), report high PPI use.
Deepika Dinesh, Xochitl C. Morgan, Hanseul Kim, Tammy M. Scott, Mahdi Garelnabi, Jong Soo Lee, Kelsey M. Mangano, Long H. Nguyen, Curtis Huttenhower, Katherine L. Tucker, Natalia Palacios   +10 more
wiley   +1 more source

Is reflux hypersensitivity truly a functional gastrointestinal disorder? A retrospective cross-sectional study.

PLoS ONE
BackgroundAccording to Rome IV, reflux hypersensitivity (RH) represents a novel form of functional esophageal disorder. This study was designed to compare the clinical features of three types of endoscopic-negative heartburn: RH, nonerosive reflux ...
Yanping Wu, Siyu Liao, Tianyao Qu, Jiaxuan Zhou, Fei Dai, Bin Qin, Xiaoyu Xu, Jun Zhang, Yan Cheng   +8 more
doaj   +1 more source

Effects of the Rome IV Criteria to Functional Dyspepsia Symptoms in Saudi Arabia: Epidemiology and Clinical Practice

The Korean Journal of Gastroenterology, 2020
Background/Aims: Limited data is available in Saudi Arabia (SA) regarding the prevalence of functional dyspepsia (FD) symptoms and its subtypes, as defined by the ROME IV criteria. This study evaluated the burden of self-reported FD symptoms in the adult
Georgios Zacharakis, Sameer Al-Ghamdi, Jamaan AlZahrani, Abdulaziz Almasoud, Omar Arahmane, Abdullah AlShehri, Moaz Hassan Alharbi, Manal Mahmood Alsalmi, Sultan Bander Alotibi, Yasameen Abdullah Algaradi, Fatimah Nassir Alsadiq, Pavlos Nikolaidis   +11 more
doaj   +1 more source

Beyond BMI: Practical Guide for Clinicians to Integrate the Lancet Commission's Obesity Framework and King's Obesity Staging System

Clinical Obesity, Volume 16, Issue 1, February 2026.
ABSTRACT Body mass index (BMI) on its own is a poor diagnostic and staging tool for obesity because it does not measure health status. The newly published Lancet Clinical Obesity Criteria (LCOC) for defining clinical obesity distinguish preclinical and clinical obesity based on organ or tissue dysfunction.
Tak Ying Louise Ko, Alexander D. Miras, Dimitri J. Pournaras, Carel W. Le Roux   +3 more
wiley   +1 more source