Results 91 to 100 of about 10,268,847 (308)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Atypical Integration of Sensory-to-Transmodal Functional Systems Mediates Symptom Severity in Autism

Frontiers in Psychiatry, 2021
A notable characteristic of autism spectrum disorder (ASD) is co-occurring deficits in low-level sensory processing and high-order social interaction. While there is evidence indicating detrimental cascading effects of sensory anomalies on the high-order
Shinwon Park, Shinwon Park, Koen V. Haak, Han Byul Cho, Han Byul Cho, Sofie L. Valk, Sofie L. Valk, Richard A. I. Bethlehem, Richard A. I. Bethlehem, Michael P. Milham, Michael P. Milham, Boris C. Bernhardt, Adriana Di Martino, Seok-Jun Hong, Seok-Jun Hong, Seok-Jun Hong   +15 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Many-electron expansion: A density functional hierarchy for strongly correlated systems

, 2016
Density functional theory (DFT) is the de facto method for the electronic structure of weakly correlated systems. But for strongly correlated materials, common density functional approximations break down.
Tianyuan Zhu, Piotr de Silva, H. van Aggelen, T. V. Van Voorhis   +3 more
semanticscholar   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Acoustic transport in higher-order topological insulators with Dirac hierarchy

New Journal of Physics, 2023
Dirac cones (DCs) are an important band structure in topological insulators (TIs) for realizing topological phase transition, and they provide unique ways to artificially regulate wave transport.
Xinglong Yu, Xin Zhang, Li Luo, Licheng Wang, Jiebin Peng, Yingyi Huang, Yuan Guo, Jing Cai, Yanping Wang, Degang Zhao, Yuanwei Yao, Fugen Wu   +11 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Systematically altered connectome gradient in benign childhood epilepsy with centrotemporal spikes: Potential effect on cognitive function

NeuroImage: Clinical
Objective: Benign childhood epilepsy with centrotemporal spikes (BECTS) affects brain network hierarchy and cognitive function; however, it remains unclear how hierarchical change affects cognition in patients with BECTS. A major aim of this study was to
Jie Hu, Guiqin Chen, Zhen Zeng, Haifeng Ran, Ruoxi Zhang, Qiane Yu, Yuxin Xie, Yulun He, Fuqin Wang, Xuhong Li, Kexing Huang, Heng Liu, Tijiang Zhang   +12 more
doaj   +1 more source

A touch of hierarchy: population receptive fields reveal fingertip integration in Brodmann areas in human primary somatosensory cortex [PDF]

, 2021
Several neuroimaging studies have shown the somatotopy of body part representations in primary somatosensory cortex (S1), but the functional hierarchy of distinct subregions in human S1 has not been adequately addressed.
Thio, Martijn, Winawer, Jonathan, Ramsey, Nick, Schellekens, Wouter, Badde, Stephanie, Petridou, Natalia, Brain, Projectafdeling functional imaging, Highfield Research Group   +8 more
core  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source