Results 81 to 90 of about 10,268,847 (308)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Total Functions in the Polynomial Hierarchy.
, 2021 We identify several genres of search problems beyond NP for which existence of solutions is guaranteed. One class that seems especially rich in such problems is PEPP (for "polynomial empty pigeonhole principle"), which includes problems related to existence theorems proved through the union bound, such as finding a bit string that is far from all ...
Robert Kleinberg +3 more
openaire +3 more sources
Axiomatic characterization of transit functions of hierarchies
Ars Mathematica Contemporanea, 2017 Summary: Transit functions provide a unifying approach to many results on intervals, convexities, and betweenness. Here we show that hierarchical structures arising in cluster analysis and phylogenetics have a natural characterization in terms of transit functions and that hierarchies are identified by multiple combinations of independent axioms.
Manoj Changat +2 more
openaire +7 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Difference Hierarchies for nT τ-functions
International Journal of Mathematics, 2018 We introduce hierarchies of difference equations (referred to as [Formula: see text]-systems) associated to the action of a (centrally extended, completed) infinite matrix group [Formula: see text] on [Formula: see text]-component fermionic Fock space. The solutions are given by matrix elements ([Formula: see text]-functions) for this action.
Darlayne Addabbo, Maarten Bergvelt
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Cell Systems, 2015 Summary Highly redundant pathways often contain components whose functions are difficult to decipher from the responses induced by genetic or molecular perturbations.
Kwonmoo Lee +6 more
semanticscholar +1 more source
, 2018 Similarity network analysis (left) uses edge thresholds to identify clusters that are progressively more similar to each other. As an example of molecular functional hierarchy, the Structure-Function Linkage Database (SFLD) hierarchy is shown on the ...
Jacquelyn S. Fetrow (277393) +1 more
core +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source