Results 61 to 70 of about 44,309 (264)

Existence of solutions of an integral equation of Chandrasekhar type in the theory of radiative transfer

Electronic Journal of Differential Equations, 2006
We give an existence theorem for some functional-integral equations which includes many key integral and functional equations that arise in nonlinear analysis and its applications.
Josefa Caballero, Angelo B. Mingarelli, Kishin Sadarangani   +2 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Equi-asymptotically almost periodic functions and applications to functional integral equations

Electronic Journal of Differential Equations, 2013
In this article, we introduce the notion of equi-asymptotically almost periodicity, and investigate some properties of equi-asymptotically almost periodic functions. In addition, by applying the results on equi-asymptotically almost periodic functions,
Hui-Sheng Ding, Qing-Long Liu, Gaston M. N'Guerekata"   +2 more
doaj  

Global attractivity for Volterra type Hadamard fractional integral equations in Fréchet spaces

Demonstratio Mathematica, 2018
In this paper, we present some results concerning the existence and the attractivity of solutions for some functional integral equations of Hadamard fractional order. We use an extension of the Burton-Kirk fixed point theorem in Fréchet spaces.
Abbas Saïd, Agarwal Ravi P., Benchohra Mouffak, Berhoun Farida   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Existence Results for Some Nonlinear Functional-Integral Equations in Banach Algebra with Applications

International Journal of Analysis and Applications, 2016
In the present manuscript, we prove some results concerning the existence of solutions for some nonlinear functional-integral equations which contains various integral and functional equations that considered in nonlinear analysis and its applications ...
Lakshmi Narayan Mishra, H. M. Srivastava, Mausumi Sen   +2 more
doaj   +2 more sources

Results on Uniqueness of Solution of Nonhomogeneous Impulsive Retarded Equation Using the Generalized Ordinary Differential Equation

International Journal of Differential Equations, 2019
In this work, we consider an initial value problem of a nonhomogeneous retarded functional equation coupled with the impulsive term. The fundamental matrix theorem is employed to derive the integral equivalent of the equation which is Lebesgue integrable.
D. K. Igobi, U. Abasiekwere
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source