Results 81 to 90 of about 44,309 (264)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Adjoint systems and Green functionals for second-order linear integro-differential equations with nonlocal conditions

Electronic Journal of Differential Equations, 2015
In this work, we generalize so called Green's functional concept in literature to second-order linear integro-differential equation with nonlocal conditions. According to this technique, a linear completely nonhomogeneous nonlocal problem for a second-
Ali Sirma
doaj  

Integral formula for elliptic SOS models with domain walls and a reflecting end

Nuclear Physics B, 2015
In this paper we extend previous work of Galleas and the author to elliptic sos models. We demonstrate that the dynamical reflection algebra can be exploited to obtain a functional equation characterizing the partition function of an elliptic sos model ...
Jules Lamers
doaj   +1 more source

Differential and integral equations with Henstock–Kurzweil integrable functions

Journal of Mathematical Analysis and Applications, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Gap Phenomenon of an Abstract Willmore Type Functional of Hypersurface in Unit Sphere

The Scientific World Journal, 2014
For an n-dimensional hypersurface in unit sphere, we introduce an abstract Willmore type called Wn,F-Willmore functional, which generalizes the well-known classic Willmore functional. Its critical point is called the Wn,F-Willmore hypersurface, for which
Yanqi Zhu, Jin Liu, Guohua Wu
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

An Innovative Approach to the Product of k-Hybrid Functional Integral Equation

Abstract and Applied Analysis
MSC2020 Classification: 46E30, 45G10, 47H30, 47N20, and ...
A. M. A. El-Sayed, Sh. M. Al-Issa
doaj   +1 more source