Results 81 to 90 of about 26,373 (304)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dhage Iteration Method for Generalized Quadratic Functional Integral Equations

International Journal of Analysis and Applications, 2015
In this paper we prove the existence as well as approximations of the solutions for a certain nonlinear generalized quadratic functional integral equation.
Bapurao C. Dhage
doaj   +2 more sources

Approximations of solutions to nonlinear Sobolev type evolution equations

Electronic Journal of Differential Equations, 2003
In the present work we study the approximations of solutions to a class of nonlinear Sobolev type evolution equations in a Hilbert space. These equations arise in the analysis of the partial neutral functional differential equations with unbounded delay.
Dhirendra Bahuguna, Reeta Shukla
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Some existence results for a nonlinear q-integral equations via M.N.C and fixed point theorem Petryshyn

Boundary Value Problems
The paper focuses on establishing sufficient conditions for the existence of the solutions in some functional q-integral equations, particularly in Banach spaces.
Hamid Reza Sahebi, Manochehr Kazemi, Mohammad Esmael Samei   +2 more
doaj   +1 more source

Efficient numerical methods for Volterra integral equations of Hammerstein type

, 2006
Volterra integral equations (VIEs) are the mathematical model of many evolutionary problems with memory arising from biology, chemistry, physics, engineering.
Del Prete, Ida
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

On some nonlinear alternatives of Leray-Schauder type and functional integral equations [PDF]

, 2006
summary:In this paper, some new fixed point theorems concerning the nonlinear alternative of Leray-Schauder type are proved in a Banach algebra. Applications are given to nonlinear functional integral equations in Banach algebras for proving the ...
Dhage, Bapurao Chandra
core  

Finite size effects and the supersymmetric sine-Gordon models [PDF]

, 2003
We propose nonlinear integral equations to describe the groundstate energy of the fractional supersymmetric sine-Gordon models. The equations encompass the N = 1 supersymmetric sine-Gordon model as well as the phi(id,id,adj) perturbation of the SU(2)(L ...
Dunning, Clare
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source