Results 111 to 120 of about 731,823 (276)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Factors Affecting the Elderly Self-Perceived Health Status
Sālmand, 2008 Objectives: The main purpose of this study is to investigate the elderly cognition of functional limitation, activity limitation, mental disorder and social and demographic characteristics (socioeconomic status, education, working status, sex and age ...
Mohammad Mirzaie
doaj
Scientific ReportsThe prevalence of depression is increasing in low- and middle-income countries (LMICs) such as India; migration is often associated with this rise. Nevertheless, there is limited knowledge about the moderating effect of functional limitations in the ...
Bittu Mandal, Kalandi Charan Pradhan
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Differential Item Functioning of the Jaw Functional Limitation Scale [PDF]
J Oral Facial Pain Headache, 2023 Pattanaik S, John MT, Chung S, Keller S.
europepmc +1 more source
Capacidad funcional y factores asociados en pacientes con espondilitis anquilopoyética
Revista Cubana de MedicinaIntroducción: la limitación funcional y la discapacidad son las consecuencias fundamentales para los pacientes con espondilitis anquilopoyética, diversos factores han sido relacionados con la discapacidad y su repercusión en la calidad de vida de estos ...
Nelsa Casas Figueredo +4 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Sarcopenia and obesity: gender-different relationship with functional limitation in older persons.
, 2013 Age-related body composition changes such as sarcopenia and obesity affect functional decline in the elderly. We investigated the relationship between body composition parameters and functional limitation in older Korean adults.
Cho, NH +8 more
core +1 more source