Results 111 to 120 of about 4,222,887 (283)

Impact of health conditions on daily functioning in Kenyan populations: A scoping review

African Journal of Disability
Background: Kenya faces significant challenges in addressing the impact of various health conditions. Understanding the functioning problems associated with these conditions is crucial for informing targeted interventions and improving overall healthcare
Naomi W. Kingau, Quinette A. Louw, Maria Y. Charumbira   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Development of a questionnaire assessing Buruli ulcer-induced functional limitation

, 2004
Buruli ulcer, a disease with long-term consequences, is emerging in west Africa. Thus, a functional limitation scoring system is needed to assess its nature and severity. A list of daily activities was developed for this disease.
Deepak, S., van der Werf, T.S., Guedenon, A., Mensah, T., Klutse, E.Y., Johnson, R.C., Ampadu, E.O., Stienstra, Y., Etuaful, S., Dijkstra, P.U., van der Graaf, W.T.   +10 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Later-life migration and depression among older adults in India: examining the role of functional limitations

Scientific Reports
The prevalence of depression is increasing in low- and middle-income countries (LMICs) such as India; migration is often associated with this rise. Nevertheless, there is limited knowledge about the moderating effect of functional limitations in the ...
Bittu Mandal, Kalandi Charan Pradhan
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Effect of Pharmaceutical Innovation on the Functional Limitations of Elderly Americans Evidence from the 2004 National Nursing Home Survey [PDF]

I examine the effect of pharmaceutical innovation on the functional status of nursing home residents using cross-sectional, patient-level data from the 2004 National Nursing Home Survey. This was the first public-use survey of nursing homes that contains
Frank R. Lichtenberg
core  

Capacidad funcional y factores asociados en pacientes con espondilitis anquilopoyética

Revista Cubana de Medicina
Introducción: la limitación funcional y la discapacidad son las consecuencias fundamentales para los pacientes con espondilitis anquilopoyética, diversos factores han sido relacionados con la discapacidad y su repercusión en la calidad de vida de estos ...
Nelsa Casas Figueredo, Jelsys Vidal Rojas, Dionisio Pérez Campos, Concepción Castell Pérez, Ángela Gutiérrez Rojas   +4 more
doaj  

Factors Affecting the Elderly Self-Perceived Health Status

Sālmand, 2008
Objectives: The main purpose of this study is to investigate the elderly cognition of functional limitation, activity limitation, mental disorder and social and demographic characteristics (socioeconomic status, education, working status, sex and age ...
Mohammad Mirzaie
doaj