Results 101 to 110 of about 731,823 (276)

The Effect of Pharmaceutical Innovation on the Functional Limitations of Elderly Americans Evidence from the 2004 National Nursing Home Survey [PDF]

I examine the effect of pharmaceutical innovation on the functional status of nursing home residents using cross-sectional, patient-level data from the 2004 National Nursing Home Survey. This was the first public-use survey of nursing homes that contains
Frank R. Lichtenberg
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Functional groups, species and light interact with nutrient limitation during tropical rainforest sapling bottleneck

, 2017
1. Potential variability in nutrient limitation among tree size classes, functional groups, and species calls for an integrated community- and ecosystem-level perspective of lowland tropical rainforest nutrient limitation.
Cleo B. Chou, Lars O. Hedin, Stephen W. Pacala, Pacala, Stephen W., Chou, Cleo B., Hedin, Lars O.   +5 more
core   +1 more source

Validity and Reliability of the Persian Version of Profile Fitness Mapping Neck Questionnaire [PDF]

Physical Treatments
Purpose: Many available questionnaires fail to distinguish between the severity of symptoms and functional limitations caused by neck pain in different areas.
Mostafa Jalili Bafrouei, Mohammadreza Seyedi, Seyed Hossein Mirkarimpour   +2 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Data from: Functional groups, species, and light interact with nutrient limitation during tropical rainforest sapling bottleneck

, 2017
1. Potential variability in nutrient limitation among tree size classes, functional groups, and species calls for an integrated community- and ecosystem-level perspective of lowland tropical rainforest nutrient limitation.
Pacala, Stephen W., Chou, Cleo B., Hedin, Lars O.   +2 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Impact of health conditions on daily functioning in Kenyan populations: A scoping review

African Journal of Disability
Background: Kenya faces significant challenges in addressing the impact of various health conditions. Understanding the functioning problems associated with these conditions is crucial for informing targeted interventions and improving overall healthcare
Naomi W. Kingau, Quinette A. Louw, Maria Y. Charumbira   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source