Results 51 to 60 of about 900,963 (349)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Variation in the oxytocin receptor gene is associated with behavioral and neural correlates of empathic accuracy

Frontiers in Behavioral Neuroscience, 2014
The neuromodulators oxytocin and serotonin have been implicated in regulating affective processes underlying empathy. Understanding this dependency, however, has been limited by a lack of objective metrics for measuring empathic performance.
Helle Ruff Laursen, Hartwig Roman Siebner, Hartwig Roman Siebner, Tina eHaren, Tina eHaren, Kristoffer eMadsen, Rikke eGroenlund, Oliver eHulme, Susanne eHenningsson, Susanne eHenningsson   +9 more
doaj   +1 more source

More than just statics: Static and temporal dynamic changes in intrinsic brain activity in unilateral temporal lobe epilepsy

Frontiers in Human Neuroscience, 2022
BackgroundTemporal lobe epilepsy (TLE) is the most prevalent refractory focal epilepsy and is more likely accompanied by cognitive impairment. The fully understanding of the neuronal activity underlying TLE is of great significance.ObjectiveThis study ...
Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Yajun Lian, Xianchang Zhang, Jinxia Zhu, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng   +58 more
doaj   +1 more source

Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN

, 2020
This handbook describes methods for processing and analyzing functional connectivity Magnetic Resonance Imaging (fcMRI) data using the CONN toolbox. The first chapter (fMRI minimal preprocessing pipeline) describes standard and advanced preprocessing ...
Alfonso Nieto-Castanon
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Switchable ROS generator and scavenger to prevent the cisplatin induced acute kidney injury and improve efficacy via synergistic chemodynamic/immune therapy

Materials Today Bio
Acute kidney injury (AKI) induced by cisplatin (DDP), which is accompanied with the generation of reactive oxygen species (ROS), is a severe side effect during treatment and restricts the application of DDP.
Yanan Ren, Fei Wu, Linlin Huo, Xiao Wang, Yong Zhang, Mengke Fan, Mingya Tan, Jiayi Zhao, Jingliang Cheng, Zhenghuan Zhao, Jianfeng Bao   +10 more
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Facile synthesis of Gd/Ru-doped fluorescent carbon dots for fluorescent/MR bimodal imaging and tumor therapy

Journal of Nanobiotechnology
Functional metal doping endows fluorescent carbon dots with richer physical and chemical properties, greatly expanding their potential in the biomedical field.
Yupeng Shi, Yaning Xia, Mengyang Zhou, Yifei Wang, Jianfeng Bao, Yong Zhang, Jingliang Cheng   +6 more
doaj   +1 more source

fMRI reveals neural activity overlap between adult and infant pain

eLife, 2015
Limited understanding of infant pain has led to its lack of recognition in clinical practice. While the network of brain regions that encode the affective and sensory aspects of adult pain are well described, the brain structures involved in infant ...
Sezgi Goksan, Caroline Hartley, Faith Emery, Naomi Cockrill, Ravi Poorun, Fiona Moultrie, Richard Rogers, Jon Campbell, Michael Sanders, Eleri Adams, Stuart Clare, Mark Jenkinson, Irene Tracey, Rebeccah Slater   +13 more
doaj   +1 more source

Meta-analysis of structural and functional brain alterations in internet gaming disorder

Frontiers in Psychiatry, 2022
BackgroundMany neuroimaging studies have reported abnormalities in brain structure and function in internet gaming disorder (IGD). However, the findings were divergent.
Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang   +79 more
doaj   +1 more source