Results 221 to 230 of about 218,183 (280)

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Altered self-processing brain networks in paediatric functional neurological disorder. [PDF]

Neuroimage Clin
Walpola IC, Mohan A, Foster S, Kozlowska K.   +3 more
europepmc   +1 more source

Functional neurological disorder: defying dualism

World Psychiatry
Stone, Jon; id_orcid 0000-0001-9829-8092, Hoeritzauer, Ingrid, Mcwhirter, Laura, Carson, Alan   +3 more
openaire   +3 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Modulating the sense of agency in functional neurological disorder using real-time fMRI neurofeedback: a proof-of-concept study. [PDF]

Neuroimage Clin
Müller E, Loukas S, Häuselmann S, Concetti C, Van De Ville D, Gninenko N, Aybek S.   +6 more
europepmc   +1 more source

Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes. [PDF]

World J Clin Pediatr
Al-Beltagi M, Saeed NK, Bediwy AS, Bediwy EA, Elbeltagi R.   +4 more
europepmc   +1 more source

Delineating network integration and segregation in the pathophysiology of functional neurological disorder. [PDF]

Brain Commun
Westlin C, Guthrie AJ, Bleier C, Finkelstein SA, Maggio J, Ranford J, MacLean J, Godena E, Millstein D, Paredes-Echeverri S, Freeburn J, Adams C, Stephen CD, Diez I, Perez DL.   +14 more
europepmc   +1 more source

Neurometabolic network (NMetNet) for functional neurological disorder in children and adolescents. [PDF]

Neuroimage Clin
Lan Z, Foster S, Charney M, van Grinsven M, Breedlove K, Kozlowska K, Lin A.   +6 more
europepmc   +1 more source

Using natural language processing to explore differences in healthcare professionals' language on Functional Neurological Disorder: a comparative topic and sentiment analysis study. [PDF]

Front Digit Health
Mashuk MS, Lu Y, Lai LYH, Shardlow M, Saha S, Williams A, Lee A, Lloyd S, Mohanraj R, Di Basilio D.   +9 more
europepmc   +1 more source