Results 81 to 90 of about 120,490 (305)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Irving S. Cooper (1922-1985): a pioneer in functional neurosurgery [PDF]

, 1998
journal articleIrving S. Cooper (1922-1985), the son of a salesman, worked his way through high school, college, and medical school to become one of the pioneers in functional neurosurgery.
Couldwell, William T., Das, Kaushik; Benzil, Deborah L.; Rovit, Richard L.; Murali, Raj   +1 more
core  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Long-term follow-up after stereotactic radiosurgery of intracanalicular acoustic neurinoma

Radiation Oncology, 2017
Background The management of solely intracanalicular acoustic neurinoma (iAN) includes observation, microsurgical resection and radiation therapy.
Daniel Rueß, Lea Pöhlmann, Stefan Grau, Christina Hamisch, Alexandra Hellerbach, Harald Treuer, Martin Kocher, Maximilian I. Ruge   +7 more
doaj   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Congress Memorys of the "I International Congress in Neurology, Neurosurgery, Neuropsychiatry and Clinical, Functional and Advanced Neuropsychology": Congress Memorys of the "I International Congress in Neurology, Neurosurgery, Neuropsychiatry and Clinical, Functional and Advanced Neuropsychology"

, 2023
Congress Memorys of the "I International Congress in Neurology, Neurosurgery, Neuropsychiatry and Clinical, Functional and Advanced ...
Hurtado González, Carlos Alberto, Hurtado González, Juan Carlos   +1 more
core   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

Advanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan, Hongming Li, Camille Blaine, Julie Grier, Ethan Hammett, Almaris Figueroa‐Gonzalez, Sarai Garcia, Romain Duprat, Justin Reber, Joseph Deluisi, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan, Desmond J. Oathes   +13 more
wiley   +1 more source

Depressive symptoms can negatively influence patient reported disease severity after subthalamic nucleus stimulation for Parkinson's disease

Journal of Parkinson’s Disease
Background Depression can negatively influence an individual's perception of their disease. Although subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson's disease (PD), some patients do not appreciate benefits ...
Christine Girges, Alexis de Roquemaurel, Nirosen Vijiaratnam, Jennifer Foley, Joseph Candelario, Maricel Salazar, Catherine Milabo, John Esperida, Tim Grover, Harith Akram, Jonathan Hyam, Marie T Krüger, Ludvic Zrinzo, Patricia Limousin, Thomas Foltynie   +14 more
doaj   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Evaluation of Surgical Treatment and the Relationship between Thoracolumbar Injury Severity and Classification Score and Preoperative Cross-Sectional Area in Patients with Thoracolumbar and Lumbar Burst Fractures

International Clinical Neuroscience Journal, 2017
Background: The aim of the study was to establish a correlation between (1) the Thoracolumbar Injury Severity and Classification score (TLICS) and sensory scores and motors scores of the American Spinal Injury Association (ASIA) Scale (surgical outcome);
Parisa Azimi, Shirzad Azhari, Edward C. Benzel, Sohrab sadeghi, Hossein Nayeb Aghaei, Hassan Reza Mohammadi, Hamid Reza Khayat Kashani, Shervin Matin-rohani   +7 more
doaj   +1 more source