A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis [PDF]
Intensive Care Medicine Experimental, 2020 Background Acute bacterial meningitis is a disease with a high mortality and a high incidence of neurological sequelae in survivors. There is an acute need to develop new adjuvant therapies.
Jane Fisher +6 more
doaj +10 more sources
Vision evaluation by functional observational battery, operant behavior test, and light/dark box test in retinal dystrophic RCS rats versus normal rats [PDF]
Heliyon, 2019 Background: Vision plays a key role in some behavior tests for rats. Okayama University-type retinal prosthesis (OUReP) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons.
Toshihiko Matsuo +7 more
doaj +2 more sources
Development of a Functional Observational Battery in the Minipig for Regulatory Neurotoxicity Assessments [PDF]
International Journal of Toxicology, 2017 A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the preclinical safety pharmacology testing guidelines. Minipigs have increasingly been used in regulatory toxicology studies; however, no current FOB protocol is available for neurotoxicity testing in these species.
Miao, Zhong +9 more
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A Performance Standard for Clinical and Functional Observational Battery Examinations of Rats [PDF]
Journal of the American College of Toxicology, 1996 Clinical examinations are a key component of all toxicology studies and are a major component of the functional observational battery (FOB). The FOB is a core feature of the USEPA neurotoxicity screening guideline of 1991. The need for well-trained technicians is recognized, but technician competency is virtually always judged subjectively by their ...
Pamela J Spencer, Ralph R Albee
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Evaluation of Effect Profiles: Functional Observational Battery Outcomes [PDF]
Fundamental and Applied Toxicology, 1997 The Functional Observational Battery (FOB) is a neurotoxicity screening assay composed of 25-30 descriptive, scalar, binary, and continuous endpoints. These outcomes have been grouped into six biologically logical domains as a means to interpret the neuroactive properties of tested chemicals (V. C. Moser, 1992, J. Am. Coll. Toxicol.
Louise Ryan, John Evans
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Journal of Pharmacopuncture, 2011 Objectives: This study was performed to analyse the effects of Sweet Bee Venom(Sweet BV-pure melittin, the major component of honey bee venom) on the central nervous system in rats.
Joong Chul An, Ki Rok Kwon
doaj +2 more sources
Advanced imaging–integrated rTMS therapy for frontal network recovery after traumatic brain injury [PDF]
Frontiers in Human NeuroscienceBackgroundTraumatic brain injury is frequently followed by persistent executive dysfunction linked to disruption of frontal and frontoparietal networks.
Nan Hu +4 more
doaj +2 more sources
Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice. [PDF]
Neurotoxicology, 2012 Synthetic stimulants commonly sold as "bath salts" are an emerging abuse problem in the U.S. Users have shown paranoia, delusions, and self-injury. Previously published in vivo research has been limited to only two components of bath salts (mephedrone and methylone).
Marusich JA +3 more
europepmc +4 more sources
Social functioning profiles, attention skills and learning: what relationships in early childhood? [PDF]
Frontiers in PsychologyBackgroundEarly learning emerges from the interplay between cognitive processes and social experiences. While attention is widely recognized as a core foundation of preschool learning, less is known about whether distinct aspects of attention contribute ...
Elena Commodari +2 more
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Data Evaluation and Statistical Analysis of Functional Observational Battery Data Using a Linear Models Approach [PDF]
Journal of the American College of Toxicology, 1989 Statistical analysis of functional observational battery (FOB) data presents special problems in that there are three different types of data collected (continuous, count, and categorical), all of which are measured in a repeated manner across time.
exaly +2 more sources