Quantification of atropine sulphate monohydrate and obidoxime dichloride in two‐chamber autoinjectors for accessing uniformity of dosage [PDF]
Analytical Science Advances, 2022 In the treatment of organophosphate poisoning atropine sulphate monohydrate (AT) and obidoxime dichloride (OB) play a vital role. Currently, the Austrian Armed Forces use the DOUBLEPEN OA two‐chamber autoinjector (ChemProtect) to administer these two ...
Iva Spreitzer +4 more
doaj +3 more sources
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their
Hyun Myung Lee +13 more
doaj +4 more sources
Cholinergic syndrome: a case report of acute organophosphate and carbamate poisoning [PDF]
Arhiv za Higijenu Rada i Toksikologiju, 2020 Cholinergic syndrome is a common topic at western medical universities yet rarely observed in clinical practice. The treatment involves muscarinic antagonists, acetylcholinesterase reactivation, seizure control, and supportive measures.
Petreski Tadej +4 more
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The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime [PDF]
Frontiers in Neuroscience, 2019 Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Dietrich E. Lorke +2 more
doaj +5 more sources
A case report of severe pirimiphos-methyl intoxication: Clinical findings and cholinesterase status [PDF]
Frontiers in Pharmacology, 2022 A 63-year-old male was admitted to a district hospital after ingesting ethanol and pirimiphos-methyl (PM) with suicidal intentions. History included alcoholic cirrhosis with alcoholism, adiposity, diabetes with cerebral microangiopathy, chronic renal ...
Tobias Zellner +6 more
doaj +2 more sources
FDA-Approved Oximes and Their Significance in Medicinal Chemistry [PDF]
Pharmaceuticals, 2022 Despite the scientific advancements, organophosphate (OP) poisoning continues to be a major threat to humans, accounting for nearly one million poisoning cases every year leading to at least 20,000 deaths worldwide.
Jyothi Dhuguru +2 more
doaj +2 more sources
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE ...
David Malinak +13 more
doaj +2 more sources
Stability of Multicomponent Antidote Parenteral Formulations for Autoinjectors against Chemical War Agents (Neurotoxics) [PDF]
PharmaceuticsCombinations of different drugs are formulated in autoinjectors for parenteral administration against neurotoxic war agents. In this work, the effects on the chemical stability of the following three variables were studied: (i) type of drug combination ...
María José Rodríguez Fernández +4 more
doaj +2 more sources
Severe organophosphate intoxication without classic cholinergic signs: A case report and updated literature review [PDF]
Science ProgressOrganophosphate compounds such as dichlorvos, a widely used pesticide, account for a substantial proportion of acute poisonings globally. These agents irreversibly inhibit acetylcholinesterase, leading to cholinergic overstimulation.
Ulkar Naghizade +5 more
doaj +2 more sources
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). This compound was designed
Jorge Alberto Valle da Silva +4 more
doaj +2 more sources