Results 31 to 40 of about 706 (177)
Autocatalytic Degradation and Stability of Obidoxime
Journal of Pharmacy and Pharmacology, 1999 Abstract The degradation of obidoxime chloride (toxogonin), a reactivator of inhibited cholinesterase in organophosphorus poisoning, in concentrated (250 mg mL−1) acidic solutions was studied by HPLC at several temperatures to determine the degradation mechanism.
S, Rubnov +4 more
openaire +2 more sources
The Influence of Oxime Selection on the Efficacy of Antidotal Treatment of Soman-Poisoned Rats
Acta Medica, 2002 1. The influence of some acetylcholinesterase reactivators (HI-6, obidoxime, pralidoxime) on the efficacy of antidotal treatment to eliminate soman-induced disturbance of respiration and circulation and to protect experimental animals poisoned with ...
Jiří Kassa, Josef Fusek
doaj +1 more source
Neuroprotective Effects of Antidotes in Soman-Poisoned Rats
Acta Medica, 1999 1. The neuroprotective effects of antidotes (atropine, obidoxime/atropine mixture, HI-6/atropine mixture) on rats poisoned with soman at a sublethal dose (48 μg/kg i.m.; 60% of LD50 value) were studied.
Jiří Kassa, Marie Koupilová
doaj +1 more source
Obidoxime Reactivation of Organophosphate-Inhibited Cholinesterase Activity in Pigs [PDF]
Acta Veterinaria Scandinavica, 1984 The ability of obidoxime to reactivate organophosphate-inhibited cholinesterases was studied in pigs treated with either trichlorfon, dichlorvos or coumaphos. In 6 pigs Cholinesterase activity was measured in the blood samples both before and after in vitro reactivation with obidoxime.
N, Gyrd-Hansen, I, Kraul
openaire +2 more sources
Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice
Acta Medica, 2004 The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice.
Lucie Bartošová +3 more
doaj +1 more source
Cholinergic syndrome: a case report of acute organophosphate and carbamate poisoning
Arhiv za Higijenu Rada i Toksikologiju, 2020 Cholinergic syndrome is a common topic at western medical universities yet rarely observed in clinical practice. The treatment involves muscarinic antagonists, acetylcholinesterase reactivation, seizure control, and supportive measures.
Petreski Tadej +4 more
doaj +1 more source
THE EFFECTS OF OXIMES IN THE ASSAY OF ACETYLCHOLINESTERASE ACTIVITY IN LYSED ERYTHROCYTES IN VITRO [PDF]
Acta Medica Iranica, 1997 Organophosphorus compounds are known to inhibit the esteratic site of acetylcholinesterase by phosphorylation. The phosphorylated esteratic site of acetylcholinesterase undergoes hydrolytic regeneration at a slow or negligible rate.
M. Abdollahi. +1 more
doaj +1 more source
Prognostic and Immunological Value of CTNNB1 in Pancreatic Adenocarcinoma: A Comprehensive NGS and Multicomponent Analysis [PDF]
Genet Res (Camb)Background To explore the prognostic value and immunomodulatory role of CTNNB1 in pancreatic ductal adenocarcinoma (PDAC), so as to provide evidence for the diagnosis and individualized treatment of PDAC. Methods Next‐generation sequencing (NGS) was performed to detect 425 cancer‐associated genes in PDAC specimens and matched normal pancreatic tissues.
Liu S, Wu Y, Zhou H, Ding Y.
europepmc +2 more sources
Electrocardiographic Findings and Prognostic Value of Long QTc Interval in Acute Organophosphate Insecticide Poisoning [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2016 Organophosphorus (OP) insecticides are one of the most important pesticides, and poisoning induced by them is a major global health problem with about 3 million intoxications and 300,000 deaths occurring worldwide every year.
Essam Hafez +2 more
doaj +1 more source
Drug Testing and Analysis, Volume 12, Issue 7, Page 938-947, July 2020., 2020 A HPLC‐DAD method was developed and validated for single and simultaneous quantification of obidoxime, pralidoxime, and HI‐6 for pharmacokinetic studies and clinical samples. Abstract Oximes such as pralidoxime (2‐PAM), obidoxime (Obi), and HI‐6 are the only currently available therapeutic agents to reactivate inhibited acetylcholinesterase (AChE) in ...
Tamara Kranawetvogl +3 more
wiley +1 more source