Results 31 to 40 of about 678 (141)
Neuroprotective Effects of Antidotes in Soman-Poisoned Rats
Acta Medica, 1999 1. The neuroprotective effects of antidotes (atropine, obidoxime/atropine mixture, HI-6/atropine mixture) on rats poisoned with soman at a sublethal dose (48 μg/kg i.m.; 60% of LD50 value) were studied.
Jiří Kassa, Marie Koupilová
doaj +1 more source
Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice
Acta Medica, 2004 The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice.
Lucie Bartošová +3 more
doaj +1 more source
THE EFFECTS OF OXIMES IN THE ASSAY OF ACETYLCHOLINESTERASE ACTIVITY IN LYSED ERYTHROCYTES IN VITRO [PDF]
Acta Medica Iranica, 1997 Organophosphorus compounds are known to inhibit the esteratic site of acetylcholinesterase by phosphorylation. The phosphorylated esteratic site of acetylcholinesterase undergoes hydrolytic regeneration at a slow or negligible rate.
M. Abdollahi. +1 more
doaj +1 more source
Drug Testing and Analysis, Volume 12, Issue 7, Page 938-947, July 2020., 2020 A HPLC‐DAD method was developed and validated for single and simultaneous quantification of obidoxime, pralidoxime, and HI‐6 for pharmacokinetic studies and clinical samples. Abstract Oximes such as pralidoxime (2‐PAM), obidoxime (Obi), and HI‐6 are the only currently available therapeutic agents to reactivate inhibited acetylcholinesterase (AChE) in ...
Tamara Kranawetvogl +3 more
wiley +1 more source
Electrocardiographic Findings and Prognostic Value of Long QTc Interval in Acute Organophosphate Insecticide Poisoning [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2016 Organophosphorus (OP) insecticides are one of the most important pesticides, and poisoning induced by them is a major global health problem with about 3 million intoxications and 300,000 deaths occurring worldwide every year.
Essam Hafez +2 more
doaj +1 more source
Electrocardiographic Findings and Prognostic Value of Long QTc Interval in Acute Organophosphate Insecticide Poisoning [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2015 Organophosphorus (OP) insecticides are one of the most important pesticides, and poisoning induced by them is a major global health problem with about 3 million intoxications and 300,000 deaths occurring worldwide every year.
Ahmad El-Ebiary +2 more
doaj +1 more source
Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering
Advanced Science, Volume 7, Issue 1, January 8, 2020., 2020 Butyrylcholinesterase (BChE)‐polymer‐oxime conjugates are synthesized by in situ atom transfer radical polymerization and azide‐alkyne “click” chemistry. The conjugate's activity depends on the electrostatic properties of the polymers and the oxime to BChE ratio.
Libin Zhang +7 more
wiley +1 more source
Organophosphorus Nerve Agents: Types, Toxicity, and Treatments
Journal of Toxicology, Volume 2020, Issue 1, 2020., 2020 Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in terrorist activities.
Sudisha Mukherjee +2 more
wiley +1 more source
Paraoxon and obidoxime inhibit thrombin activity in vitro.
, 2016 (A) Varying concentrations of paraoxon (500 nM, 5 μM, 28 μM, 50 μM, 0.28 mM and 0.5 mM) inhibit thrombin activity. (B) Obidoxime inhibits thrombin activity at varying concentrations.
Valery Golderman (3186672) +8 more
core +1 more source
Prognostic and Immunological Value of CTNNB1 in Pancreatic Adenocarcinoma: A Comprehensive NGS and Multicomponent Analysis [PDF]
Genet Res (Camb)Background To explore the prognostic value and immunomodulatory role of CTNNB1 in pancreatic ductal adenocarcinoma (PDAC), so as to provide evidence for the diagnosis and individualized treatment of PDAC. Methods Next‐generation sequencing (NGS) was performed to detect 425 cancer‐associated genes in PDAC specimens and matched normal pancreatic tissues.
Liu S, Wu Y, Zhou H, Ding Y.
europepmc +2 more sources