Results 21 to 30 of about 706 (177)
Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. [PDF]
Chemistry, 2022 Rational design of efficient antidotes to organophosphorus nerve agent (OPNA) intoxication needs to account for the complexity of the molecular system. A fragment with broad‐spectrum binding profile was transformed into a multi‐active reactivator of OPNAs‐inhibited acetylcholinesterases.
Lindgren C +9 more
europepmc +2 more sources
Organophosphate Poisoning: Insights From a Case Report of Acute Cholinergic Syndrome. [PDF]
Clin Case RepABSTRACT Organophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine. A 45‐year‐old male plumber was admitted to the emergency department 4 h after ingesting an unknown quantity of a 50% emulsifiable concentration of ...
Bereda G.
europepmc +2 more sources
Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]
Clin Case RepABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK +3 more
europepmc +2 more sources
pH-metric investigation of the system containing palladium(II) ion and obidoxime chloride
, 1997 The formation of a complex between palladium (II) chloride obidoxime chloride has been studied by means of pH-metric measurements. Thee mean value of the real stability constant of the complex in aqueous medium of ionic strengths 0.55 M and 1.0 M (KCl ...
Rajković, MB +1 more
core +7 more sources
REACTIVATION POTENCY OF THE ACETYLCHOLINESTERASE REACTIVATOR OBIDOXIME IS LIMITED [PDF]
Biomedical Papers, 2009 Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed.
Kamil, Kuca +4 more
openaire +2 more sources
Pro: Oximes should be used routinely in organophosphate poisoning
British Journal of Clinical Pharmacology, Volume 88, Issue 12, Page 5064-5069, December 2022., 2022 In poisoning with organophosphorus compounds (OP), patients can only profit from the regeneration of acetylcholinesterase, when the poison load has dropped below a toxic level. Every measure that allows an increase of synaptic acetylcholinesterase (AChE) activity at the earliest is essential for timely termination of the cholinergic crisis.
Horst Thiermann, Franz Worek
wiley +1 more source
Archiv der Pharmazie, Volume 355, Issue 11, November 2022., 2022 Significant effort has been invested into the development of cholinesterase reactivators that are capable of treating organophosphorus poisoning. A series of 12 coumarin derivatives equipped with linker‐connected nonaromatic terminal amino moieties were prepared in this study.
Paul W. Elsinghorst +6 more
wiley +1 more source
A CASE STUDY OF NEONATAL ORGANOPHOSPHATE POISONING PRESENTED AS ACUTE RESPIRATORY DISTRESS [PDF]
The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2022 Introduction: Organophosphate poisoning [OP] is a likely fatal but completely manageable condition that is still quite common in our country. Early diagnosis is crucial in preventing fatality. Although rarely reported, it occurs in infants.
Mokhtar Abdel-satar +3 more
doaj +1 more source
, 2022 S.506-513The standard treatment of poisoning by organophosphorous compounds such as paraoxon includes the administration of oximes. Due to their inability to rapidly cross the blood-brain barrier (BBB) in therapeutically relevant concentrations, these ...
Worek, F. +4 more
core +1 more source
Advanced Therapeutics, Volume 4, Issue 1, January 2021., 2021 Targeting of the brain has been achieved by apolipoprotein E‐functionalization of drug‐loaded polymeric nanoparticles via different approaches to treat central nervous system (CNS) diseases such as Alzheimer's disease or cerebral cancer. After in vitro and in vivo evaluation, nanoparticle recognition by low density lipoprotein‐receptors and crossing of
Natascha Hartl +2 more
wiley +1 more source