Results 21 to 30 of about 1,015 (193)
Archiv der Pharmazie, Volume 355, Issue 11, November 2022., 2022 Significant effort has been invested into the development of cholinesterase reactivators that are capable of treating organophosphorus poisoning. A series of 12 coumarin derivatives equipped with linker‐connected nonaromatic terminal amino moieties were prepared in this study.
Paul W. Elsinghorst +6 more
wiley +1 more source
Advanced Therapeutics, Volume 4, Issue 1, January 2021., 2021 Targeting of the brain has been achieved by apolipoprotein E‐functionalization of drug‐loaded polymeric nanoparticles via different approaches to treat central nervous system (CNS) diseases such as Alzheimer's disease or cerebral cancer. After in vitro and in vivo evaluation, nanoparticle recognition by low density lipoprotein‐receptors and crossing of
Natascha Hartl +2 more
wiley +1 more source
Obidoxime Reactivation of Organophosphate-Inhibited Cholinesterase Activity in Pigs [PDF]
Acta Veterinaria Scandinavica, 1984 The ability of obidoxime to reactivate organophosphate-inhibited cholinesterases was studied in pigs treated with either trichlorfon, dichlorvos or coumaphos. In 6 pigs Cholinesterase activity was measured in the blood samples both before and after in vitro reactivation with obidoxime.
N, Gyrd-Hansen, I, Kraul
openaire +2 more sources
Molecules, 2009 Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun +9 more
doaj +1 more source
REACTIVATION POTENCY OF THE ACETYLCHOLINESTERASE REACTIVATOR OBIDOXIME IS LIMITED [PDF]
Biomedical Papers, 2009 Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed.
Kamil, Kuca +4 more
openaire +2 more sources
Acta Medica, 2002 1. The influence of oximes (pralidoxime, obidoxime, HI-6) and anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) on the effectiveness of antidotal treatment to eliminate tabun-induced lethal effects was studied in mice. 2.
Jiří Kassa
doaj +1 more source
Acta Medica, 2010 The ability of newly developed oximes (K347, K628) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oximes (obidoxime, HI-6) using a functional observational battery.
Jiří Kassa +4 more
doaj +1 more source
Autocatalytic Degradation and Stability of Obidoxime
Journal of Pharmacy and Pharmacology, 1999 Abstract The degradation of obidoxime chloride (toxogonin), a reactivator of inhibited cholinesterase in organophosphorus poisoning, in concentrated (250 mg mL−1) acidic solutions was studied by HPLC at several temperatures to determine the degradation mechanism.
S, Rubnov +4 more
openaire +2 more sources
Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos [PDF]
Vojnosanitetski Pregled, 2011 Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy.
Antonijević Biljana +3 more
doaj +1 more source
Chlorpyrifos-Induced Delayed Neurotoxicity with A Rare Presentation of Flaccid Quadriplegia: A Diagnostic Challenge [PDF]
, 2017 Chlorpyrifos is an organophosphate compound recognized as causing acute toxicity. However, organophosphate-induced delayed polyneuropathy (OPIDP), although rare, has also been described.
Afonso Mendes, Patrícia +3 more
core +3 more sources