Results 1 to 10 of about 821 (107)

Pralidoxime improves the hemodynamics and survival of rats with peritonitis-induced sepsis.

PLoS ONE, 2021
Several studies have suggested that sympathetic overstimulation causes deleterious effects in septic shock. A previous study suggested that pralidoxime exerted a pressor effect through a mechanism unrelated to the sympathetic nervous system; this effect ...
Najmiddin Mamadjonov, Yong Hun Jung, Kyung Woon Jeung, Hyoung Youn Lee, Byung Kook Lee, Chun Song Youn, In Seok Jeong, Tag Heo, Yong Il Min   +8 more
doaj   +2 more sources

Effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model [PDF]

Clinical and Experimental Emergency Medicine, 2019
Objective Pralidoxime is widely used for the treatment of organophosphate poisoning. Multiple studies have reported its vasoconstrictive property, which may facilitate the restoration of spontaneous circulation (ROSC) after cardiac arrest by increasing ...
Yong Hun Jung, Dong Hyun Ryu, Kyung Woon Jeung, Joo-Young Na, Dong Hun Lee, Byung Kook Lee, Tag Heo, Yong Il Min   +7 more
doaj   +3 more sources

Evaluation of Pralidoxime Use in an Iranian Teaching Referral Hospital [PDF]

Pharmaceutical Sciences, 2018
Background: Organophosphorus (OP) poisonings, a common source of pesticide poisoning, are an important cause of morbidity and mortality in the developing countries.
Ali Banagozar Mohammadi, Maryam Zaare Nahandi, Negin Raad, Siroos Javani, Afshin Gharekhani   +4 more
doaj   +2 more sources

Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. [PDF]

PLoS Medicine, 2009
BackgroundPoisoning with organophosphorus (OP) insecticides is a major global public health problem, causing an estimated 200,000 deaths each year.
Michael Eddleston, Peter Eyer, Franz Worek, Edmund Juszczak, Nicola Alder, Fahim Mohamed, Lalith Senarathna, Ariyasena Hittarage, Shifa Azher, K Jeganathan, Shaluka Jayamanne, Ludwig von Meyer, Andrew H Dawson, Mohamed Hussain Rezvi Sheriff, Nick A Buckley   +14 more
doaj   +3 more sources

Effects of Different Doses of Pralidoxime Administered During Cardiopulmonary Resuscitation and the Role of α‐Adrenergic Receptors in Its Pressor Action

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background We previously reported that pralidoxime facilitated restoration of spontaneous circulation by potentiating the pressor effect of epinephrine. We determined the optimal dose of pralidoxime during cardiopulmonary resuscitation and evaluated the ...
Yong Hun Jung, Najmiddin Mamadjonov, Hyoung Youn Lee, Kyung Woon Jeung, Byung Kook Lee, Chun Song Youn, Tag Heo, Yong Il Min   +7 more
doaj   +1 more source

Effects of Organophosphorus and Pyrethroid pesticides on antioxidant enzymes and reactivation effects of Pralidoxime: In vitro studies

Kuwait Journal of Science, 2022
The aim of this work was to investigate the inhibition effects of some organophosphate and pyrethroid pesticides on antioxidant enzymes. In addition, oximes were reported by reactivation ability against pesticide inhibited-acetylcholinesterase and we ...
Hatice Paluzar, Ayten Sagiroglu
doaj   +1 more source

Organophosphorus Poisoning with Homicidal Intention in a Neonate

Indian Journal of Neonatal Medicine and Research, 2022
Organophosphorus Compounds (OPC) are widely used as pesticides, and poisoning due to OPC is very rare in neonates. A 12-day- old female neonate was admitted with gasping respiration, excessive oral secretions and cold extremities.
Laxman Basany, Roja Aepalapala
doaj   +1 more source

FDA-Approved Oximes and Their Significance in Medicinal Chemistry

Pharmaceuticals, 2022
Despite the scientific advancements, organophosphate (OP) poisoning continues to be a major threat to humans, accounting for nearly one million poisoning cases every year leading to at least 20,000 deaths worldwide.
Jyothi Dhuguru, Eugene Zviagin, Rachid Skouta   +2 more
doaj   +1 more source

Treatment of Organophosphorus Exposure and Precautions in Using Succinylcholine

Archives of Anesthesia and Critical Care, 2023
   
Ali Jabbari, Atabak Najafi, Vahid Khori, Zahid Hussain Khan   +3 more
doaj   +1 more source

Safety and Efficacy of New Oximes to Reverse Low Dose Diethyl-Paraoxon-Induced Ventilatory Effects in Rats

Molecules, 2020
Background: Oximes are used in addition to atropine to treat organophosphate poisoning. However, the efficiency of oximes is still a matter of debate. In vitro experiments suggested than new oximes are more potent than the commercial oximes. However, the
Maya Kayouka, Pascal Houzé, Marc Lejay, Frédéric J. Baud, Kamil Kuca   +4 more
doaj   +1 more source