Results 41 to 50 of about 2,868 (201)

Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study [PDF]

, 2015
There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity.
Abdu Adem, Huba Kalasz, Kornelia Tekes, Mohammad Shafiullah, Shreesh Ojha, Syed M. Nurulain   +5 more
core   +3 more sources

What Target Pralidoxime Concentration? [PDF]

Journal of Toxicology: Clinical Toxicology, 1997
(1997). What Target Pralidoxime Concentration? Journal of Toxicology: Clinical Toxicology: Vol. 35, No. 2, pp. 227-228.
Andrew Dawson, Nick Buckley, Ian Whyte
openaire   +1 more source

Self injection of Dichlorvos, an Organophosphorus Compound [PDF]

, 2008
We report two patients who injected themselves a strong organophosphate compound, dichlorvas, and showed the typical clinical picture of organophosphate intoxication. There are very few case reports of parenteral organophosphorous poisoning.
DM, Mahesh, Gupta, Dalip, Kaushal, Satinder Singh, Raina, Sujeet, Sood, Vivek   +4 more
core   +1 more source

Acute collapse in a dog with multiple autoimmune syndromes and polymyositis complicated by suspected organophosphate/carbamate toxicity

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 6.5‐year‐old, spayed, female dog presented in acute respiratory distress. On admission, the dog exhibited dyspnoea, bradycardia, cyanosis and gastrointestinal signs, requiring immediate intubation and mechanical ventilation. Diagnostic evaluation revealed reduced butyrylcholinesterase activity, non‐cardiogenic pulmonary oedema, elevated ...
Sarah Hefer, Efrat Kelmer, Michal Mazaki Tovi, Dana Peery, Kobi Aharoni, Nir Edry, Sigal Klainbart   +6 more
wiley   +1 more source

Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning

Scientific Reports, 2022
Pesticides account for hundreds of millions of cases of acute poisoning worldwide each year, with organophosphates (OPs) being responsible for the majority of all pesticide-related deaths.
Sarah Piel, Joanna I. Janowska, J. Laurenson Ward, Meagan J. McManus, Joshua S. Jose, Jonathan Starr, Malkah Sheldon, Carly L. Clayman, Eskil Elmér, Magnus J. Hansson, David H. Jang, Michael Karlsson, Johannes K. Ehinger, Todd J. Kilbaugh   +13 more
doaj   +1 more source

Intermediate Syndrome After Organophosphate Poisoning: Clinical Course and a Case of Delayed Neuromuscular Dysfunction

Case Reports in Critical Care, Volume 2026, Issue 1, 2026.
Intermediate syndrome (IMS) is a delayed neuromuscular complication of organophosphate poisoning, typically occurring 24–96 h postexposure and often leading to respiratory failure. The author reports a 39‐year‐old male who ingested 40% chlorpyrifos and developed IMS on Day 4 post‐ingestion, presenting with proximal muscle weakness, neck flexor ...
Gudisa Bereda, Lipi Buch
wiley   +1 more source

Antidote administration in mice exposed to sarin resulted in brainwave stabilization without cognitive protection

Neuroscience Research
Resurgence of sarin use in the Syrian conflict demonstrates that chemical weapons are a vivid threat. Like other organophosphate compounds, sarin inhibits acetylcholinesterase resulting in cholinergic crisis.
Mélanie Lagadec, Pauline Thiebot, Isabelle Malissin, Alexandre Champault, Julie Somkhit, Julie Knoertzer, Assia Belkebir, Bruno Megarbane, Karine Thibault, Gregory Dal Bo   +9 more
doaj   +1 more source

Computational Design, Molecular Docking Study and Toxicity Prediction of Some Novel Pralidoxime Derivatives as reactivators of acetyl cholinesterase enzyme [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: oximes as Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate compounds (OPCs) intoxication.
abozar roeintan
doaj  

Nanometric MIL-125-NH2 Metal–Organic Framework as a Potential Nerve Agent Antidote Carrier

Nanomaterials, 2017
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe ...
Sérgio M. F. Vilela, Pablo Salcedo-Abraira, Isabelle Colinet, Fabrice Salles, Martijn C. de Koning, Marloes J. A. Joosen, Christian Serre, Patricia Horcajada   +7 more
doaj   +1 more source

Survival pattern in patients with acute organophosphate poisoning on mechanical ventilation: A retrospective intensive care unit-based study in a tertiary care teaching hospital

Indian Journal of Anaesthesia, 2014
Background and Aims: Organophosphorus (OP) compound poisoning is one of the most common poisonings in India. The aim of the study was to study the outcomes and predictors of mortality in patients with acute OP poisoning requiring mechanical ventilation ...
Syed M Ahmed, Bikramjit Das, Abu Nadeem, Rajiv K Samal   +3 more
doaj   +1 more source