Results 1 to 10 of about 5,697 (170)
The Structural Diversity and Biological Activity of Steroid Oximes
Molecules, 2023 Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included.
Ana R. Gomes +3 more
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Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells
Arhiv za Higijenu Rada i Toksikologiju, 2022 Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death.
Zandona Antonio +4 more
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Molecules, 2020 Background: Oximes are used in addition to atropine to treat organophosphate poisoning. However, the efficiency of oximes is still a matter of debate. In vitro experiments suggested than new oximes are more potent than the commercial oximes. However, the
Maya Kayouka +4 more
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New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases
Pharmaceuticals, 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading ...
Milena Mlakić +8 more
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Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential
Biomolecules, 2021 Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin +4 more
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Determination of ionization constants for some oxymes derived from benzyl compounds and heterocyclic aromatics [PDF]
مجلة التربية والعلم, 2005 This research is concerned with the preparation of four aliphatic or aromatic oximes, prepared from benzil and heterocyclic aldehydes and the determination of their pKa by potentiometric method.
Adel Azzoz +2 more
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Recent Advances in N-O Bond Cleavage of Oximes and Hydroxylamines to Construct N-Heterocycle
Molecules, 2023 Oximes and hydroxylamines are a very important class of skeletons that not only widely exist in natural products and drug molecules, but also a class of synthon, which have been widely used in industrial production.
Hui-Min Jiang +4 more
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Acta Medica, 2016 Aim: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats.
Jiří Kassa +2 more
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Nanoparticulate transport of oximes over an in vitro blood-brain barrier model. [PDF]
PLoS ONE, 2010 BACKGROUND: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Sylvia Wagner +9 more
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Synthesis of Trifluoromethylated Monoterpene Amino Alcohols
Molecules, 2022 For the first time, monoterpene trifluoromethylated β-hydroxy-benzyl-O-oximes were synthesized in 81–95% yields by nucleophilic addition of the Ruppert–Prakash reagent (TMSCF3) to the corresponding β-keto-benzyl-O-oximes based on (+)-nopinone ...
Polina A. Petrova +5 more
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