Results 11 to 20 of about 10,063 (262)

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model [PDF]

PLoS ONE, 2010
Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Tikva Vogel, Kreuter, Jörg (Prof. Dr.), Sascha Wien, Zensi, Anja, Kufleitner, Jürgen, Jörg Kreuter, Wien, Sascha, Jürgen Kufleitner, Bungert, Judith, Wagner, Sylvia, Judith Bungert, Dadparvar, Miriam, Vogel, Tikva, Anja Zensi, Sylvia Wagner, Worek, Franz, Miriam Dadparvar, Hagen von Briesen, Briesen, Hagen von, Franz Worek   +19 more
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The Structural Diversity and Biological Activity of Steroid Oximes

Molecules, 2023
Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included.
Elisiário J. Tavares-da-Silva, Ana R. Gomes, Fernanda M. F. Roleira, Ana S. Pires   +3 more
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Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential

Biomolecules, 2021
Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin, Andrei I. Khlebnikov, Mark B. Plotnikov, Tatiana M. Plotnikova, Mark T. Quinn   +4 more
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Pharmacokinetic Studies on Oximes in Organophosphate Poisoning: A Mini Review [PDF]

Asia Pacific Journal of Medical Toxicology, 2014
Organophosphate (OP) poisoning is one of the most common causes of poisoning in developing countries especially in Southeastern Asia. Poisoning with phosphorus-containing organic chemicals or OP compounds can be managed with antidotes like oximes which ...
Sreedharan Nair, Sudha Vidyasagar, Sureshwar Pandey, Rama Mylapuri, Girish Thunga, Vijayanarayana Kunhikatta, Akriti Kaura   +6 more
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A Comparison of the Potency of Newly Developed Oximes (K347, K628) and Currently Available Oximes (Obidoxime, HI-6) to Counteract Acute Neurotoxic Effects of Tabun in Rats

Acta Medica, 2010
The ability of newly developed oximes (K347, K628) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oximes (obidoxime, HI-6) using a functional observational battery.
Jana Žďárová Karasová, Kamil Musílek, Kamil Kuča, Jiří Kassa, Sandra Tesařová   +4 more
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Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Acta Medica, 2006
In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested.
Jan Pícha, Kamil Kuča, Daniel Jun
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A Comparison of the Neuroprotective Efficacy of Newly Developed Oximes (K156, K203) and Currently Available Oximes (Obidoxime, HI-6) in Cyclosarin-poisoned Rats

Acta Medica, 2008
The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied.
Jana Žďárová Karasová, Kamil Musílek, Kamil Kuča, Jiří Kassa, Sandra Tesařová   +4 more
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Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells

Arhiv za Higijenu Rada i Toksikologiju, 2022
Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death.
Zandona Antonio, Zorbaz Tamara, Miš Katarina, Pirkmajer Sergej, Katalinić Maja   +4 more
doaj   +1 more source

Safety and Efficacy of New Oximes to Reverse Low Dose Diethyl-Paraoxon-Induced Ventilatory Effects in Rats

Molecules, 2020
Background: Oximes are used in addition to atropine to treat organophosphate poisoning. However, the efficiency of oximes is still a matter of debate. In vitro experiments suggested than new oximes are more potent than the commercial oximes. However, the
Maya Kayouka, Pascal Houzé, Marc Lejay, Frédéric J. Baud, Kamil Kuca   +4 more
doaj   +1 more source

New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases

Pharmaceuticals, 2021
The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading ...
Milena Mlakić, Tena Čadež, Danijela Barić, Ivana Puček, Ana Ratković, Željko Marinić, Kornelija Lasić, Zrinka Kovarik, Irena Škorić   +8 more
doaj   +1 more source