Nanoparticulate transport of oximes over an in vitro blood-brain barrier model. [PDF]
PLoS ONE, 2010 BACKGROUND: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Sylvia Wagner +9 more
doaj +4 more sources
Ceria–Zirconia-Supported Pt as an Efficient Catalyst for the Sustainable Synthesis of Hydroxylamines and Primary Amines via the Hydrogenation of Oximes Under Ambient Conditions [PDF]
MoleculesAmines and hydroxylamines are essential compounds in the synthesis of pharmaceuticals and other functionalized molecules. However, the synthesis of primary amines and particularly hydroxylamines remains a challenging task.
Elena Redina +5 more
doaj +2 more sources
Manganese catalyzed oximation of hydrocarbons to oximes. [PDF]
Nat CommunAbstract Oximes are used in many scientific and industrial domains, ranging from organic synthesis through biotechnology to materials science. Traditionally, their synthesis necessitates the use of hydrocarbons with specific functional groups, such as carbonyls, which are often more challenging and expensive to obtain compared to their non ...
Song M +10 more
europepmc +2 more sources
The Structural Diversity and Biological Activity of Steroid Oximes
Molecules, 2023 Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included.
Ana R. Gomes +3 more
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Acta Crystallographica Section E Structure Reports Online, 2008 In the crystal structure of the title compound, C(7)H(8)N(2)O, mol-ecules are connected via inter-molecular N-H⋯O and O-H⋯N hydrogen bonds to form a two-dimensional supra-molecular structure. The oxime group has an E configuration and the dihedral angle between the mean planes of the benzene ring and the amidoxime grouping is 20.2 (3)°.
Shu-Qing Xu, Jia-Ming Li
openaire +3 more sources
Cytotoxicity-related effects of imidazolium and chlorinated bispyridinium oximes in SH-SY5Y cells
Arhiv za Higijenu Rada i Toksikologiju, 2022 Current research has shown that several imidazolium and chlorinated bispyridinium oximes are cytotoxic and activate different mechanisms or types of cell death.
Zandona Antonio +4 more
doaj +1 more source
Molecules, 2020 Background: Oximes are used in addition to atropine to treat organophosphate poisoning. However, the efficiency of oximes is still a matter of debate. In vitro experiments suggested than new oximes are more potent than the commercial oximes. However, the
Maya Kayouka +4 more
doaj +1 more source
New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases
Pharmaceuticals, 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading ...
Milena Mlakić +8 more
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Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential
Biomolecules, 2021 Oximes have been studied for decades because of their significant roles as acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have been reported with useful pharmaceutical properties, including compounds with ...
Igor A. Schepetkin +4 more
doaj +1 more source
Determination of ionization constants for some oxymes derived from benzyl compounds and heterocyclic aromatics [PDF]
مجلة التربية والعلم, 2005 This research is concerned with the preparation of four aliphatic or aromatic oximes, prepared from benzil and heterocyclic aldehydes and the determination of their pKa by potentiometric method.
Adel Azzoz +2 more
doaj +1 more source