Results 31 to 40 of about 10,063 (262)

Novel centrally active oxime reactivators of acetylcholinesterase inhibited by surrogates of sarin and VX

Neurobiology of Disease, 2020
A novel oxime platform, the substituted phenoxyalkyl pyridinium oximes (US patent 9,227,937), was invented at Mississippi State University with an objective of discovering a brain-penetrating antidote to highly potent organophosphate anticholinesterases,
Janice E. Chambers, Edward C. Meek
doaj   +1 more source

The Synthesis of Novel aza-Steroids and α, β-Unsaturated-Cyanoketone from Diosgenin

Molecules, 2023
Recent studies have demonstrated the antiproliferative and cytotoxic effects of aza-steroids and steroidal sapogenins on human cancer cell lines. The scientific community has shown a growing interest in these compounds as drug candidates for cancer ...
Dayana Mesa, Yarelys E. Augusto, Giselle Hernández, Juan P. Figueroa-Macías, Francisco Coll, Andrés F. Olea, María Núñez, Hernán Astudillo Campo, Yamilet Coll, Luis Espinoza   +9 more
doaj   +1 more source

Functionalised oximes : emergent precursors for carbon-, nitrogen- and oxygen-centred radicals

, 2016
The author thanks EaStCHEM for financial support.Oxime derivatives are easily made, are non-hazardous and have long shelf lives. They contain weak N–O bonds that undergo homolytic scission, on appropriate thermal or photochemical stimulus, to initially ...
John C. Walton, Walton, John Christopher, John Walton   +2 more
core   +1 more source

Structural chemistry of oximes [PDF]

, 2013
Oximes (RR'C=N-OH) represent an important class of organic compounds with a wide range of practical applications, but a systematic examination of the structural chemistry of such compounds has so far not been carried out.
Sinha, Abhijeet Shekhar, Aakeröy, Christer B., Epa, Kanishka N., Smith, Michelle M., Chopade, Prashant D., Desper, John   +5 more
core   +1 more source

One-Pot Synthesis of Dioxime Oxalates

Molbank, 2022
Dioxime oxalates, a type of carbonyl oximes, are well-known as clean sources of iminyl radicals that undergo key organic chemistry transformations. A series of dioxime oxalates is reported in this manuscript, obtained by the reaction of the corresponding
Laura Adarve-Cardona, David Ezenarro-Salcedo, Mario A. Macías, Diego Gamba-Sánchez   +3 more
doaj   +1 more source

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes

, 2019
α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base.
Wenwei Lin, Praneeth Karanam, Tsai-Hui Lung (6714734), Athukuri Edukondalu, Athukuri Edukondalu (1393036), Chi-Yi Wu (6714737), Yi-Jung Lin (19416), Praneeth Karanam (6714743), Wenwei Lin (278782), Srinivasa Rao Koppolu, Tsai-Hui Lung, Chi-Yi Wu, Pankaj V. Khairnar (6714731), Yi-Jung Lin, Pankaj V. Khairnar, Srinivasa Rao Koppolu (6714740)   +15 more
core   +1 more source

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

Biomolecules, 2021
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life.
Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajda   +6 more
doaj   +1 more source

Catalytic Functionalization of Unactivated π‐Bonds Enabled by Bidentate Directing Auxiliaries

Angewandte Chemie, EarlyView.
This review explores how bidentate directing auxiliaries have advanced transition‐metal catalysis for unactivated alkene/alkyne functionalization. By leveraging chelated intermediates, bidentate directing auxiliaries enable precise hydrofunctionalization, difunctionalization, and C─H activation of π‐bonds with unique selectivity and reactivity.
Seunghyeon Cho, Al Vicente Riano D. Lisboa, Juntao Sun, Taeho Kang, Keary M. Engle   +4 more
wiley   +2 more sources

Oximes as Drugs [PDF]

, 2009
Name: Jana Švehlová Title: Oximes as Drugs Thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Programme: Pharmacy This thesis aims at the processing data about existing and potential drugs of the oximes and amidoximes groups ...
Švehlová, Jana
core   +1 more source

Results of in vivo and in vitro experiments with oximes as antidotes against sarin and soman poisoning

, 2022
S.109-113 : Ill., Lit.The toxic effects of nerve agents and organophosphorous pesticides are mainly due to inhibition of AChE by phosphorylation of its active site.
Greve, J., Oldiges, H., Wenzel, A., Wasmus, G., Fliedner, A.   +4 more
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