Results 31 to 40 of about 11,166 (254)

Novel centrally active oxime reactivators of acetylcholinesterase inhibited by surrogates of sarin and VX

Neurobiology of Disease, 2020
A novel oxime platform, the substituted phenoxyalkyl pyridinium oximes (US patent 9,227,937), was invented at Mississippi State University with an objective of discovering a brain-penetrating antidote to highly potent organophosphate anticholinesterases,
Janice E. Chambers, Edward C. Meek
doaj   +1 more source

The Synthesis of Novel aza-Steroids and α, β-Unsaturated-Cyanoketone from Diosgenin

Molecules, 2023
Recent studies have demonstrated the antiproliferative and cytotoxic effects of aza-steroids and steroidal sapogenins on human cancer cell lines. The scientific community has shown a growing interest in these compounds as drug candidates for cancer ...
Dayana Mesa, Yarelys E. Augusto, Giselle Hernández, Juan P. Figueroa-Macías, Francisco Coll, Andrés F. Olea, María Núñez, Hernán Astudillo Campo, Yamilet Coll, Luis Espinoza   +9 more
doaj   +1 more source

Structural chemistry of oximes [PDF]

, 2013
Oximes (RR'C=N-OH) represent an important class of organic compounds with a wide range of practical applications, but a systematic examination of the structural chemistry of such compounds has so far not been carried out.
Sinha, Abhijeet Shekhar, Aakeröy, Christer B., Epa, Kanishka N., Smith, Michelle M., Chopade, Prashant D., Desper, John   +5 more
core   +1 more source

One-Pot Synthesis of Dioxime Oxalates

Molbank, 2022
Dioxime oxalates, a type of carbonyl oximes, are well-known as clean sources of iminyl radicals that undergo key organic chemistry transformations. A series of dioxime oxalates is reported in this manuscript, obtained by the reaction of the corresponding
Laura Adarve-Cardona, David Ezenarro-Salcedo, Mario A. Macías, Diego Gamba-Sánchez   +3 more
doaj   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Oximes as Drugs [PDF]

, 2009
Name: Jana Švehlová Title: Oximes as Drugs Thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Programme: Pharmacy This thesis aims at the processing data about existing and potential drugs of the oximes and amidoximes groups ...
Švehlová, Jana
core   +1 more source

Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase

Biomolecules, 2021
Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life.
Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajda   +6 more
doaj   +1 more source

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes

, 2019
α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base.
Wenwei Lin, Praneeth Karanam, Tsai-Hui Lung (6714734), Athukuri Edukondalu, Athukuri Edukondalu (1393036), Chi-Yi Wu (6714737), Yi-Jung Lin (19416), Praneeth Karanam (6714743), Wenwei Lin (278782), Srinivasa Rao Koppolu, Tsai-Hui Lung, Chi-Yi Wu, Pankaj V. Khairnar (6714731), Yi-Jung Lin, Pankaj V. Khairnar, Srinivasa Rao Koppolu (6714740)   +15 more
core   +1 more source

Post‐Synthetic Zinc Modifications to Correct Speciation in Ti‐MWW Zeolites for Catalytic Oxidation

Angewandte Chemie, EarlyView.
Post‐synthetic Zn modifications of Ti‐MWW zeolite catalysts exhibit improved catalytic properties in the selective oxidation reaction, namely the ammoximation reaction. The origin of the beneficial effect of Zn is related via an array of spectroscopic and microscopic techniques to the modification of extra‐framework TiO2 and TiOx clusters and the ...
Christoph J. Kaul, Lukas Lätsch, Alexander V. Yakimov, Milivoj Plodinec, Xing Huang, Trees De Baerdemaeker, Jaroslaw Mormul, Peter Oechsle, Andrei‐Nicolae Parvulescu, J. Henrique Teles, Christophe Copéret   +10 more
wiley   +2 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources