Results 1 to 10 of about 260,200 (252)

HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning [PDF]

Drug Delivery, 2023
Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that were used as chemical warfare agents. HI-6 is one of the most promising reactivators which is effective in reactivating AChE inhibited by many nerve agents.
Liao Shen, Yadan Zhang, Qimei Cai, Jun Yang, Yongan Wang, Dongqin Quan   +5 more
doaj   +3 more sources

Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates. [PDF]

ACS Omega, 2020
The deleterious effects of nerve agents over the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) turned these compounds into the most dangerous chemical weapons known.
Souza FR, Rodrigues Garcia D, Cuya T, Pimentel AS, Gonçalves ADS, Alencastro RB, França TCC.   +6 more
europepmc   +2 more sources

Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes. [PDF]

BMC Neurosci, 2014
BackgroundRecent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population.
RamaRao G, Afley P, Acharya J, Bhattacharya BK.   +3 more
europepmc   +3 more sources

Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6). [PDF]

Interdiscip Toxicol, 2013
Sulfur mustard (SM) is a blister agent with cytotoxic mechanism of action. There is no suitable treatment based on administration of an antidote. In this study, Wistar rats were exposed to SM in doses of 0-40 mg/kg body weight and treated with the ...
Pohanka M, Sobotka J, Svobodova H, Stetina R.   +3 more
europepmc   +2 more sources

Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6. [PDF]

Proc Natl Acad Sci U S A, 2016
Allgardsson A, Berg L, Akfur C, Hörnberg A, Worek F, Linusson A, Ekström FJ.   +6 more
europepmc   +2 more sources

HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. [PDF]

Chem Biol Interact, 2016
Maček Hrvat N, Žunec S, Taylor P, Radić Z, Kovarik Z.   +4 more
europepmc   +2 more sources

Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model [PDF]

Scientific Reports
About 80% of neonates with hypoxic-ischaemic encephalopathy (HIE) have cardiovascular dysfunction and are vulnerable to late-onset injury due to disrupted cerebral blood flow and metabolism.
Kosuke Sakamoto, Shinji Nakamura, Toui Tsuchiya, Tsutomu Mitsuie, Yasuhiro Nakao, Yinmon Htun, Takayuki Yokota, Kota Inoue, Eri Inoue, Takayuki Wakabayashi, Aya Morimoto, Kosuke Koyano, Yukihiko Konishi, Takashi Iwase, Taikou Horii, Takashi Kusaka   +15 more
doaj   +2 more sources

Preparation of an HI-6-loaded brain-targeted liposomes based on the nasal delivery route and the evaluation of its reactivation of central toxic acetylcholinesterase.

European Journal of Pharmaceutical Sciences, 2023
PURPOSE Organophosphorus compounds (OPs) is a serious threat to human health and life safety, but because of the existence of blood-brain barrier, most of the therapeutic drugs can not enter the center, reactivate centrally located toxic ...
Ning Fan, Qian Li, Yuan Liu, Bo Ma, Meng Li, Dong-feng Yin   +5 more
semanticscholar   +1 more source

Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury

Neurobiology of Disease, 2021
The result of a deprivation of oxygen and glucose to the brain, hypoxic–ischemic encephalopathy (HIE), remains the most common cause of death and disability in human neonates globally and is mediated by glutamate toxicity and inflammation.
O. Arteaga Cabeza, Z. Zhang, E. Smith Khoury, R.A. Sheldon, A. Sharma, F. Zhang, B.S. Slusher, R.M. Kannan, S. Kannan, D.M. Ferriero   +9 more
doaj   +1 more source

A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats.

Acta medica, 2021
AIM The comparison of neuroprotective and central reactivating effects of the oxime K870 in combination with atropine with the efficacy of standard antidotal treatment in tabun-poisoned rats.
J. Kassa, J. Hatlapatková, J. Zdarova Karasova, Vendula Hepnarova, Filip Caisberger, J. Pejchal   +5 more
semanticscholar   +1 more source