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MerTK and the Role of Phagoptosis in Neonatal Hypoxia-Ischemia [PDF]
CellsBrain damage caused by hypoxia-ischemia is a serious complication for a newborn with possible life-long sequelae. To develop targeted neuroprotective strategies, it is essential to understand the mechanisms of injury, particularly the role of microglial ...
Andrea Jonsdotter +6 more
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Exenatide Is Neuroprotective in a New Rabbit Model of Hypoxia-Ischemia [PDF]
CellsHypoxia-ischemia is a serious perinatal complication affecting neonates globally. Animal models have increased the understanding of its pathophysiology and have been used to investigate potential therapies. Exenatide, clinically used for the treatment of
Eridan Rocha-Ferreira +6 more
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Sex Vulnerabilities to Hypoxia-Ischemia at Birth.
JAMA Netw Open, 2023 This cross-sectional study examines the incidence of hypoxic ischemic encephalopathy in male vs female neonates.
Chalak LF, Pruszynski JE, Spong CY.
europepmc +3 more sources
Hypoxia–ischemia in the immature brain [PDF]
Journal of Experimental Biology, 2004 SUMMARYThe immature brain has long been considered to be resistant to the damaging effects of hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific periods of increased vulnerability, which relate to the developmental stage at the time of the insult.
Susan J, Vannucci, Henrik, Hagberg
openaire +2 more sources
Biomedicines, 2022 Hypoxia–ischemia encephalopathy results from the interruption of oxygen delivery and blood flow to the brain. In the developing brain, it can lead to a brain injury, which is associated with high mortality rates and comorbidities.
Daniela Silva +6 more
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Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic–Ischemic Brain Injury in Neonatal Mice
ASN Neuro, 2023 A clinical challenge remains in the treatment of hypoxic–ischemic brain injury in newborns. Nicotinamide adenine dinucleotide (NAD + ) has beneficial effects in animal models of adult stroke.
Takuya Kawamura +11 more
doaj +1 more source
δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia
Frontiers in Immunology, 2020 Hypoxia and ischemia are the main underlying pathogenesis of stroke and other neurological disorders. Cerebral hypoxia and/or ischemia (e.g., stroke) can lead to neuronal injury/death and eventually cause serious neurological disorders or even death in ...
Yi-Meng Chen +3 more
doaj +1 more source
A Facile Route for the Preparation of Monodisperse Iron nitride at Silica Core/shell Nanostructures
Frontiers in Bioengineering and Biotechnology, 2021 Uniform-sized iron oxide nanoparticles obtained from the solution phase thermal decomposition of the iron-oleate complex were encapsulated inside the silica shell by the reverse microemulsion technique, and then thermal treatment under NH3 to transfer ...
Hoonsub Kim +4 more
doaj +1 more source
Histology of Brain Trauma and Hypoxia-Ischemia [PDF]
Academic Forensic Pathology, 2018 Forensic pathologists encounter hypoxic-ischemic (HI) brain damage or traumatic brain injuries (TBI) on an almost daily basis. Evaluation of the findings guides decisions regarding cause and manner of death. When there are gross findings of brain trauma, the cause of death is often obvious.
Petra, Rahaman, Marc R, Del Bigio
openaire +2 more sources
MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models. [PDF]
PLoS ONE, 2015 Hypoxia inducible factor-1α facilitates cellular adaptation to hypoxic conditions. Hence its tight regulation is crucial in hypoxia related diseases such as cerebral ischemia.
Fu Jia Liu +6 more
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