Results 31 to 40 of about 432,342 (201)

Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. [PDF]

PLoS ONE, 2017
The protective effects of ilexsaponin A on ischemia-reperfusion-induced myocardial injury were investigated. Myocardial ischemia/reperfusion model was established in male Sprague-Dawley rats. Myocardial injury was evaluated by TTC staining and myocardial
Shuang-Wei Zhang, Yu Liu, Fang Wang, Jiao Qiang, Pan Liu, Jun Zhang, Jin-Wen Xu   +6 more
doaj   +1 more source

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation [PDF]

, 2007
Ischemia is a major cause of brain damage, and patient management is complicated by the paradoxical injury that results from reoxygenation. We have now explored the generation of reactive oxygen species (ROS) in hippocampal and cortical neurons in ...
SCORZIELLO, ANTONELLA, Abramov, A.Y., Duchen, M.R., Abramov AY, Scorziello, A., Duchen MR   +5 more
core   +1 more source

Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults

Mediators of Inflammation, 2015
Perinatal insults and subsequent neuroinflammation are the major mechanisms of neonatal brain injury, but there have been only scarce reports on the associations between hypoxic preconditioning and glial activation.
Chien-Yi Chen, Wei-Zen Sun, Kai-Hsiang Kang, Hung-Chieh Chou, Po-Nien Tsao, Wu-Shiun Hsieh, Wen-Mei Fu   +6 more
doaj   +1 more source

Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: Identification of potential neuroprotective candidates for stroke

Neurobiology of Disease, 2006
The aim of the present study is to better understand oxygen-sensitive adaptative pathways underlying the hypoxic preconditioning-induced protection of the brain against ischemia.
Yang Tang, Emilie Pacary, Thomas Fréret, Didier Divoux, Edwige Petit, Pascale Schumann-Bard, Myriam Bernaudin   +6 more
doaj   +1 more source

Neuronal cell death in neonatal hypoxia‐ischemia [PDF]

Annals of Neurology, 2011
AbstractPerinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and morbidity in infants and young children. Therapeutic opportunities are very limited for neonatal and pediatric HIE. Specific neural systems and populations of cells are selectively vulnerable in HIE; however, the mechanisms of degeneration are unresolved ...
Frances J, Northington, Raul, Chavez-Valdez, Lee J, Martin   +2 more
openaire   +2 more sources

Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy

Redox Biology, 2017
Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated ...
Jeannette Vasquez-Vivar, Zhongjie Shi, Kehuan Luo, Karthikeyan Thirugnanam, Sidhartha Tan   +4 more
doaj   +1 more source

Subplate in a rat model of preterm hypoxia-ischemia

Annals of Clinical and Translational Neurology, 2014
Hypoxia-ischemia (HI) in preterm infants primarily leads to injuries in the cerebral white matter. However, there is growing evidence that perinatal injury in preterms can also involve other zones including the cortical gray matter. In a neonatal rat model of HI, selective vulnerability of subplate has been suggested using BrdU birth-dating methods. In
Okusa, C., Oeschger, F., Ginet, V., Wang, W.Z., Hoerder-Suabedissen, A., Matsuyama, T., Truttmann, A.C., Molnár, Z.   +7 more
openaire   +5 more sources

Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets [PDF]

, 1998
Background and Purpose-Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I).
Domoki, Ferenc, Bari, Ferenc, Veltkamp, R.   +2 more
core   +1 more source

Treatment with docosahexaenoic acid after hypoxia-ischemia improves forepaw placing in a rat model of perinatal hypoxia-ischemia [PDF]

American Journal of Obstetrics and Gynecology, 2010
Docosahexaenoic acid (DHA) is a dietary fatty acid with neuroprotective properties. We hypothesized that DHA treatment after hypoxia-ischemia would improve function and reduce brain volume loss in a perinatal rat model.Seven-day-old Wistar rat pups from 7 litters (n = 84) underwent right carotid ligation, followed by 8% O(2) for 90 minutes.
Deborah R, Berman, YiQing, Liu, John, Barks, Ellen, Mozurkewich   +3 more
openaire   +2 more sources

PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia

JACC: Basic to Translational Science, 2023
Summary: Hypoxia-induced endothelial cell death and impaired angiogenesis are the main pathophysiological features of critical limb ischemia. Mechanistically, proprotein convertase subtilisin/kexin type 9 (PCSK9) promoted Smac translocation from ...
Meixin Zhang, MM, Yixi Chen, PhD, Yumin Qiu, PhD, Jiapan Sun, PhD, Jiang He, PhD, Zhefu Liu, MM, Jian Shi, PhD, Wenbin Wei, MD, Guifu Wu, PhD, Jianwen Liang, PhD   +9 more
doaj   +1 more source