Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat [PDF]
, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick +26 more
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Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets [PDF]
, 1998 Background and Purpose-Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I).
Domoki, Ferenc +2 more
core +1 more source
Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia
Neurobiology of Disease, 2016 Cooling to 33.5 °C in babies with neonatal encephalopathy significantly reduces death and disability, however additional therapies are needed to maximize brain protection.
Kevin D. Broad +14 more
doaj +1 more source
Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. [PDF]
PLoS ONE, 2017 The protective effects of ilexsaponin A on ischemia-reperfusion-induced myocardial injury were investigated. Myocardial ischemia/reperfusion model was established in male Sprague-Dawley rats. Myocardial injury was evaluated by TTC staining and myocardial
Shuang-Wei Zhang +6 more
doaj +1 more source
Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]
, 2005 Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core +1 more source
The spectrum of Ischemia-induced white matter injury varies with age [PDF]
, 2013 Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Zammit, Christian +2 more
core +1 more source
Neurobiology of Disease, 2006 The aim of the present study is to better understand oxygen-sensitive adaptative pathways underlying the hypoxic preconditioning-induced protection of the brain against ischemia.
Yang Tang +6 more
doaj +1 more source
Neuronal cell death in neonatal hypoxia‐ischemia [PDF]
Annals of Neurology, 2011 AbstractPerinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and morbidity in infants and young children. Therapeutic opportunities are very limited for neonatal and pediatric HIE. Specific neural systems and populations of cells are selectively vulnerable in HIE; however, the mechanisms of degeneration are unresolved ...
Frances J, Northington +2 more
openaire +2 more sources
Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults
Mediators of Inflammation, 2015 Perinatal insults and subsequent neuroinflammation are the major mechanisms of neonatal brain injury, but there have been only scarce reports on the associations between hypoxic preconditioning and glial activation.
Chien-Yi Chen +6 more
doaj +1 more source
Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy
Redox Biology, 2017 Antenatal brain hypoxia-ischemia, which occurs in cerebral palsy, is considered a significant cause of motor impairments in children. The mechanisms by which antenatal hypoxia-ischemia causes brain injury and motor deficits still need to be elucidated ...
Jeannette Vasquez-Vivar +4 more
doaj +1 more source