Results 41 to 50 of about 409,719 (296)

Subplate in a rat model of preterm hypoxia-ischemia

Annals of Clinical and Translational Neurology, 2014
Hypoxia-ischemia (HI) in preterm infants primarily leads to injuries in the cerebral white matter. However, there is growing evidence that perinatal injury in preterms can also involve other zones including the cortical gray matter. In a neonatal rat model of HI, selective vulnerability of subplate has been suggested using BrdU birth-dating methods. In
Okusa, C., Oeschger, F., Ginet, V., Wang, W.Z., Hoerder-Suabedissen, A., Matsuyama, T., Truttmann, A.C., Molnár, Z.   +7 more
openaire   +4 more sources

PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia

JACC: Basic to Translational Science, 2023
Summary: Hypoxia-induced endothelial cell death and impaired angiogenesis are the main pathophysiological features of critical limb ischemia. Mechanistically, proprotein convertase subtilisin/kexin type 9 (PCSK9) promoted Smac translocation from ...
Meixin Zhang, MM, Yixi Chen, PhD, Yumin Qiu, PhD, Jiapan Sun, PhD, Jiang He, PhD, Zhefu Liu, MM, Jian Shi, PhD, Wenbin Wei, MD, Guifu Wu, PhD, Jianwen Liang, PhD   +9 more
doaj   +1 more source

Treatment with docosahexaenoic acid after hypoxia-ischemia improves forepaw placing in a rat model of perinatal hypoxia-ischemia [PDF]

American Journal of Obstetrics and Gynecology, 2010
Docosahexaenoic acid (DHA) is a dietary fatty acid with neuroprotective properties. We hypothesized that DHA treatment after hypoxia-ischemia would improve function and reduce brain volume loss in a perinatal rat model.Seven-day-old Wistar rat pups from 7 litters (n = 84) underwent right carotid ligation, followed by 8% O(2) for 90 minutes.
Deborah R, Berman, YiQing, Liu, John, Barks, Ellen, Mozurkewich   +3 more
openaire   +2 more sources

Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation [PDF]

, 2007
Ischemia is a major cause of brain damage, and patient management is complicated by the paradoxical injury that results from reoxygenation. We have now explored the generation of reactive oxygen species (ROS) in hippocampal and cortical neurons in ...
SCORZIELLO, ANTONELLA, Abramov, A.Y., Duchen, M.R., Abramov AY, Scorziello, A., Duchen MR   +5 more
core   +1 more source

Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion [PDF]

, 1993
We examined the relationship between transsarcolemmal cation gradients and hypercontracture of cardiac myocytes in ischemia and reperfusion using adult rat ventricular myocytes superfused with buffer mimicking normal or ischemic extracellular fluid ...
J. P. Navas, Marsh, J. D., R. A. Kelly, J. D. Marsh, Krämer, Bernhard K., Kelly, R. A., Nishida, M., T. W. Smith, Smith, T. W., M. Nishida, B. Kraemer, Borzak, S., S. Borzak, Navas, J. P.   +13 more
core   +1 more source

Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels

Redox Biology, 2020
Hypertonia is pathognomonic of cerebral palsy (CP), often caused by brain injury before birth. To understand the early driving events of hypertonia, we utilized magnetic resonance imaging (MRI) assessment of early critical brain injury in rabbit fetuses (
Jeannette Vasquez-Vivar, Zhongjie Shi, Jeong-Won Jeong, Kehuan Luo, Amit Sharma, Karthikeyan Thirugnanam, Sidhartha Tan   +6 more
doaj   +1 more source

Tannic Acid Improves Renal Function Recovery after Renal Warm Ischemia–Reperfusion in a Rat Model

Biomolecules, 2020
Background and purpose: Ischemia−reperfusion injury is encountered in numerous processes such as cardiovascular diseases or kidney transplantation; however, the latter involves cold ischemia, different from the warm ischemia found in vascular ...
Louise Alechinsky, Frederic Favreau, Petra Cechova, Sofiane Inal, Pierre-Antoine Faye, Cecile Ory, Raphaël Thuillier, Benoit Barrou, Patrick Trouillas, Jerome Guillard, Thierry Hauet   +10 more
doaj   +1 more source

Roles of nitric oxide in brain hypoxia-ischemia

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999
A large body of evidence has appeared over the last 6 years suggesting that nitric oxide biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia-ischemia. Whilst studies on the influence of nitric oxide in this phenomenon initially offered conflicting conclusions, the use of better biochemical tools, such as selective ...
Bolaños, Juan P, Almeida, Angeles
openaire   +2 more sources

Neuroprotective effect of neuroglobin in hypoxia/ischemia

Сибирский научный медицинский журнал, 2021
Neuroglobin is a representative of the globin group, an oxygen-binding protein which is predominantly expressed in the nervous system. Despite the large amount of conducted research, its role is still poorly understood. It’s assumed that neuroglobin is able to regulate cell activity in health and disease:in health it provides oxygen homeostasis of ...
E. V. Uzlova, S. M. Zimatkin
openaire   +3 more sources

Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury

Neurobiology of Disease, 1996
We hypothesized that elimination of neuronal nitric oxide synthase (nNOS) by targeted disruption of the nNOS gene would result in amelioration of damage seen after hypoxia–ischemia in the developing brain since nitric oxide (NO) has been implicated in ...
Donna M. Ferriero, David M. Holtzman, Stephen M. Black, R.Ann Sheldon   +3 more
doaj   +1 more source