Results 51 to 60 of about 123,355 (307)

Cardiac Shock Wave Therapy Attenuates H9c2 Myoblast Apoptosis by Activating the AKT Signal Pathway

Cellular Physiology and Biochemistry, 2014
Background: Previous studies have demonstrated that Cardiac Shock Wave Therapy (CSWT) improves myocardial perfusion and cardiac function in a porcine model of chronic myocardial ischemia and also ameliorates myocardial ischemia in patients with severe ...
Weiwei Yu, Tao Shen, Baoyi Liu, Shu Wang, Jian Li, Dapeng Dai, Jianping Cai, Qing He   +7 more
doaj   +1 more source

Bax shuttling after neonatal hypoxia–ischemia: Hyperoxia effects [PDF]

Journal of Neuroscience Research, 2008
AbstractPerinatal hypoxia–ischemia (HI) occurs in 0.2%–0.4% of all live births, with 100% O2 resuscitation (HHI) remaining a standard clinical treatment. HI produces a broad spectrum of neuronal death phenotypes ranging from a more noninflammatory apoptotic death to a more inflammatory necrotic cell death that may be responsible for the broad spectrum ...
Martin B, Gill, Kurt, Bockhorst, Ponnada, Narayana, J Regino, Perez-Polo   +3 more
openaire   +2 more sources

Added Prognostic Value of EEG Reactivity in Comatose Patients Following Cardiac Arrest

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the added prognostic value of EEG reactivity for favorable outcome compared with background analysis during and after targeted temperature management (TTM). Methods Prospective observational cohort study of comatose post–cardiac arrest patients admitted to a single academic center between 2017 and 2022, all undergoing ...
Sarah Caroyer, Marie Obrecht, Charlotte de Maeseneire, Charlotte Damien, Chantal Depondt, Lorenzo Ferlini, Estelle Rikir, Filippo Annoni, Fabio Silvio Taccone, Nicolas Mavroudakis, Benjamin Legros, Nicolas Gaspard   +11 more
wiley   +1 more source

Hypoxia-ischemia and retinal ganglion cell damage

Clinical Ophthalmology, 2008
Retinal hypoxia is the potentially blinding mechanism underlying a number of sight-threatening disorders including central retinal artery occlusion, ischemic central retinal vein thrombosis, complications of diabetic eye disease and some types of glaucoma. Hypoxia is implicated in loss of retinal ganglion cells (RGCs) occurring in such conditions.
Charanjit Kaur, Wallace S Foulds, Eng-Ang Ling   +2 more
openaire   +4 more sources

The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia [PDF]

Developmental Neuroscience, 2018
Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms.
Jana Krystofova, Praneeti Pathipati, Jeffrey Russ, Ann Sheldon, Donna Ferriero   +4 more
openaire   +4 more sources

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Heat shock protein 70 protects PC12 cells against ischemia-hypoxia/reoxygenation by maintaining intracellular Ca2+ homeostasis

Neural Regeneration Research, 2016
Heat shock protein 70 (HSP70) maintains Ca2+ homeostasis in PC12 cells, which may protect against apoptosis; however, the mechanisms of neuroprotection are unclear.
Yuan Liu, Xue-chun Wang, Dan Hu, Shu-ran Huang, Qing-shu Li, Zhi Li, Yan Qu   +6 more
doaj   +1 more source

Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy

Cellular & Molecular Biology Letters, 2023
Background Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed graft function.
Ming Ma, Hui Li, Saifu Yin, Tao Lin, Turun Song   +4 more
doaj   +1 more source

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. [PDF]

, 2013
A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from the autophagy protein Beclin 1, to investigate whether high levels of ...
Clarke, P.G., Ginet, V., Green, D.R., Levine, B., Liu, Y., Posner, B., Puyal, J., Shaw, S.Y., Shoji-Kawata, S., Sumpter, R.M., Tran, K.A., Wei, Y., Xavier, R.J., Zhang, L.   +13 more
core   +1 more source

Splenic Immune Cells in Experimental Neonatal Hypoxia–Ischemia [PDF]

Translational Stroke Research, 2012
Neuroimmune processes contribute to hypoxic-ischemic damage in the immature brain and may play a role in the progression of particular variants of neonatal encephalopathy. The present study was designed to elucidate molecular mediators of interactions between astrocytes, neurons and infiltrating peripheral immune cells after experimental neonatal ...
Nancy, Fathali, Robert P, Ostrowski, Yu, Hasegawa, Tim, Lekic, Jiping, Tang, John H, Zhang   +5 more
openaire   +2 more sources