Results 71 to 80 of about 432,342 (201)

Bioinformatics Analysis and Experimental Validation of Key Genes Associated With Hypoxia and Ischemia in Myocardial Infarction

Molecular Genetics & Genomic Medicine
Background This study aimed to screen and identify core hypoxia‐ischemia‐related genes associated with myocardial infarction (MI). Method Two transcriptomic datasets, GSE97320 and GSE48060, were retrieved from the Gene Expression Omnibus (GEO) database ...
Longsheng Zhang, Ning Liang
doaj   +1 more source

Mouse renal 4T1 cell engraftment as a model to study the influence of hypoxia in breast cancer progression [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To develop a mouse model to study the influence of hypoxia in breast cancer progression and metastasis. METHODS: The 4T1 cell line was used to engraft the kidneys of female BALB/c mice.
Heriton Marcelo Ribeiro Antonio, Larissa Raquel Mouro Mandarano, Alan Augusto Coelho, Marcelo Guimarães Tiezzi, Jurandyr Moreira de Andrade, Daniel Guimarães Tiezzi   +5 more
doaj   +2 more sources

A comparison between chemical and gas hypoxia as models of global ischemia in zebrafish (Danio rerio)

Animal Models and Experimental Medicine, 2020
Background Zebrafish models for neurovascular diseases offer new methods for elucidation of molecular pathways to tissue damage. External fertilization and high fecundity provide opportunities for transgenics and other forms of genetic manipulation that ...
Kaitlyn M. Marino, Emani R. Silva, James A. Windelborn   +2 more
doaj   +1 more source

Lipopolysaccharide and hypoxia/ischemia induced IL-2 expression by microglia in neonatal brain

, 2008
Using a model of perinatal brain lesions induced by lipopolysaccharide and hypoxia/ischemia, we hypothesized that interleukin-2 (IL-2), a neurotoxic cytokine, was enhanced within injured brains.
Kadhim, Hazim, Sébire, Guillaume, Gobeil, Fernand, Rola-Pleszczynski, Marek, Larouche, Annie, Girard, Sylvie   +5 more
core   +1 more source

Global gene expression in the immature brain after hypoxia-ischemia

, 2004
Ischemia induces a complex response of differentially expressed genes in the brain. In order to understand the specific mechanisms of injury in the developing brain, it is important to obtain information on global changes in the transcriptome after ...
Hagberg, Henrik,, Mallard, Carina,, Eklind, Saskia,, Gustafsson Brywe, Katarina,, Hedtjärn, Maj,   +4 more
core   +2 more sources

Inflammatory gene profiling in the developing mouse brain after hypoxia-ischemia

, 2004
Brain ischemia triggers an inflammatory reaction that progresses for days to weeks and seems to have a role in secondary progression of injury. Inflammation induces a complex pattern of signaling molecules with partly contradictory actions, and the ...
Hagberg, Henrik,, Mallard, Carina,, Hedtjärn, Maj,   +2 more
core   +2 more sources

Behavioral performance of rats following neonatal hypoxia-ischemia.

, 1986
The behavioral performance of rats subjected in the neonatal period to hypoxia-ischemia at either 37 degrees C or 21 degrees C was compared to that of sham-ligated animals.
J Kolonich, S K Yagel, C L Woods, R S Young   +3 more
core   +1 more source

O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy

Cell Death and Disease
Lung transplant ischemia-reperfusion injury poses a significant challenge in transplantation medicine, often causing severe complications and poor patient outcomes.
Shaohua Dai, Xuemei Wan, Lingchun Xia, Lei Xu, Chunfan Xie, Guohui Wang, Jian Tang   +6 more
doaj   +1 more source

Detrimental Role of Corticotropin-Releasing Factor on the Decrease of CA1 Field Potential Induced by In Vitro Ischemia in Rat Hippocampal Slices

Journal of Pharmacological Sciences, 2004
This experiment was designed to test the hypothesis that endogenous corticotropin-releasing factor (CRF) contributes to the neurodegenerative process following an ischemic insult.
Yoshifumi Kagamiishi, Tsuneyuki Yamamoto, Shigenori Watanabe   +2 more
doaj   +1 more source

Effects of intermittent versus chronic hypoxia on myocardial ischemic tolerance

, 2011
Hypoxia, or low supply of oxygen with respect to need, represents a critical risk factor that augments severity and impairs outcome of myocardial ischemia. However, systemic hypoxia is sometimes a cardioprotective rather than risk factor. Three different
Samaja M., Veicsteinas A., Milano G.
core   +1 more source