Results 81 to 90 of about 432,342 (201)

Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion [PDF]

, 1993
We examined the relationship between transsarcolemmal cation gradients and hypercontracture of cardiac myocytes in ischemia and reperfusion using adult rat ventricular myocytes superfused with buffer mimicking normal or ischemic extracellular fluid ...
J. P. Navas, Marsh, J. D., R. A. Kelly, J. D. Marsh, Krämer, Bernhard K., Kelly, R. A., Nishida, M., T. W. Smith, Smith, T. W., M. Nishida, B. Kraemer, Borzak, S., S. Borzak, Navas, J. P.   +13 more
core   +1 more source

Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia

, 2002
Background and Purpose— Perinatal hypoxia-ischemia is a major cause of neonatal morbidity and mortality. Until now no established neuroprotective intervention after perinatal hypoxia-ischemia has been available.
Tweel, van den, E., Nicolaij, K., Zhu, C., Kops, N., Blomgren, K., Peeters-Scholte, C., Bär, D., Bel, van, F., Groenendaal, F., Buul-Offers, van, S., Koster, J., Veldhuis, W.B., Hagberg, H.   +12 more
core   +1 more source

Effects of Acute Systemic Hypoxia and Hypercapnia on Brain Damage in a Rat Model of Hypoxia-Ischemia. [PDF]

, 2016
Therapeutic hypercapnia has the potential for neuroprotection after global cerebral ischemia. Here we further investigated the effects of different degrees of acute systemic hypoxia in combination with hypercapnia on brain damage in a rat model of ...
Xianhai Fang (3373421), Xianhai Fang, Nan Wang (21935), Xuezhong Zhang, Tao Tao (19313), Xuezhong Zhang (3373427), Jing Tan, Qi Wang (22418), Nan Wang, Wanchao Yang, Wanchao Yang (3373424), Tao Tao, Qi Wang, Jing Tan (2230783), Wenzhi Li (617452), Wenzhi Li, Zhang Xuezhong, Wang Nan, Tan Jing, Li Wenzhi, Wang Qi, Fang Xianhai, Yang Wanchao   +22 more
core   +1 more source

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm [PDF]

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
MacAllister, R.J., Loukogeorgakis, S.P., Panagiotido, A.T., Yellon, D.M., Deanfield, J.E.   +4 more
core  

KR-33028 attenuates ischemia/hypoxia-induced blood-brain barrier hyperpermeability through maintaining tight junction integrity

, 2012
We have previously demonstrated that KR-33028, a novel inhibitor of Na+/H+ exchanger-1(NHE-1), exerts neuroprotective effects during cerebral ischemia.
Park, Sung Lyea, Yoo, Sung Eun, Lee, Sunkyung, Yi, Kyu Yang, Lee, Dong Ha, Jung, Yi-Sook   +5 more
core   +1 more source

Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]

, 1993
Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Schneider, Uwe, Poole, RC, Halestrap, Andrew P., Grafe, Peter, Grafe, P, Poole, Robert C., Schneider, U, Halestrap, AP   +7 more
core   +1 more source

Regulation of Cellular Stress Signaling in Bladder Ischemia

Research and Reports in Urology, 2020
Jing-Hua Yang,1 Yedan Li,2 Roya Azad,2 Kazem Azadzoi3 1Department of Surgery, Boston University School of Medicine, Boston, MA, USA; 2Department of Urology, VA Boston Healthcare System, Boston, MA, USA; 3Department of Urology and Department of Pathology,
Yang J, Li Y, Azad R, Azadzoi K
doaj  

Hypoxia-Induced Inos Expression in Microglia Is Regulated by the P13- Kinase/Akt/Mtor Signaling Pathway and Activation of Hypoxia Inducible Factor-1 Alpha

, 2009
Exposure to hypoxia induced microglia activation and animal studies have shown that neuronal cell death is correlated with microglial activation following cerebral ischemia.
盧大宇;湯智昕;符文美, LU, DAH-YUU;TANG, CHIH-HSIN;FU, WEN-MEI   +1 more
core  

Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury

Scientific Reports
In neonatal hypoxic-ischemic brain injury (HIBI), a common form of perinatal brain damage associated with mortality and neurological disability, the disruption of oxygen and nutrient supply severely impacts brain metabolism.
Nora Wolff, Maria Triantafyllou, Javid Ghaemmaghami, Georgios Sanidas, Chad Everett Byrd, Gabriele Simonti, Susan Aja, Aurelie Roux, Khyzer Aziz, Evan Goldstein, Jiangyang Zhang, Allen Dale Everett, David Graham, Panagiotis Kratimenos, Ioannis Koutroulis, Frances Northington   +15 more
doaj   +1 more source

Modulating mitochondrial metabolism: a neuroprotective mechanism for hypoxic–ischemic preconditioning

Cell Regeneration
Hypoxia–ischemia plays a role in the physiological and pathological processes of various diseases and presents a common challenge for humans under extreme environmental conditions.
Wenxin Li, Guo Shao, Ruifang Qi
doaj   +1 more source